Endocrine Abstracts

According to the recommendations of the European Group for the study of Graves ‘orbitopathy (EOP) (EUGOGO), pulse therapy with glucocorticosteroids, is the method of choice in active EOP of moderate severity or severe course. The choice of scheme depends largely on the doctor’s preferences, as the comparative effectiveness of many of them remains uncertain.Objective: To evaluate the effectiveness of various schemes of pulse therapy with methylp...

The routine approach to evaluating the effectiveness of diabetes treatment based on the level of glycated hemoglobin (HbA1c) accounts for the average glucose level but does not consider its fluctuations. However, recent data indicate that the development of late complications of diabetes is associated with the degree of variability in glycemia. (GV).Clinical case: Patient F. is 54-year-old woman with a 33-year history of type 1 diabetes with multiple chr...

Background: Increased production of reactive oxygen species (ROS) and oxidative stress play a significant role in the initiation and persistence of the autoimmune process in Graves’ disease (GD)Aim: To study the ROS level of peripheral blood monocytes in patients with GD after radioactive iodine (RAI). Materials and Methods: The study included 48 patients with a confirmed diagnosis of GD, from 18 to 65 years (mean 46.42 ± 1...

Introduction: Radioactive iodine (RAI) for Graves’ disease (GD) was reported to have specific immune effects. The ability of T and B lymphocytes to cooperatively interaction during the immune response may be impaired in GD patients eligible for RAI therapy. We aimed at investigating cellular subsets involved in functional activity of adaptive immunity cellsone month after RAI therapy in patients with GD.Materials and methods: Thirty-six women with G...

Background: Foxp3(+) regulatory T cells (Treg) play a leading role in developing immune tolerance through active suppression in Graves’ disease (GD). The influence of radioactive iodine therapy (RAI) on the differentiated fractions of Treg of GD patients is still poorly understood. Aim: To estimate the differentiated fractions of blood Tregs and the CD25 expression in patients with GD after RAI.Materials and Methods: In total,...