Searchable abstracts of presentations at key conferences in endocrinology

ea0011p757 | Steroids | ECE2006

11beta-hydroxysteroid dehydrogenase is an early and essential marker of human adipogenesis

Bujalska IJ , Gatherocole LL , Tomlinson JW , Darimont C , Stewart PM

The prevalence of obesity and its association with many health complications have evoked a high interest in adipose tissue metabolism. In man, glucocorticoid (GC) excess increases fat mass and the risk of developing Metabolic Syndrome. The enzyme responsible for modifying intracellular GC concentrations in adipose tissue is 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The aim of this study was to characterise the novel human preadipocyte cell line (Chub-S7) an...