Endocrine Abstracts

Pituitary development involves a number of genes encoding signaling molecules and transcription factors. Genetic mutations of any of these factors are implicated in the aetiology of congenital hypopituitarism. The phenotypes of patients with pituitary development disorders might be highly variable depending on the type and severity of deficiencies and the age of diagnosis. A diagnosis of congenital pituitary hormone deficiency must be suspected when other causes of hypopituita...

Objectives: This study aimed to assess the ability of aldosterone in saline infusion test (SIT) to predict biochemical remission of primary aldosteronism.Methods: We retrospectively analysed 42 patients (19 (45%) females, mean age 49±12 years) with primary aldosteronism who underwent adrenalectomy (after adrenal vein sampling confirmation of unilateral disease) from 2017 to 2022. Aldosterone in SIT was determined on the fifth postoperative day, as wel...

The aim of this study was to compare the long-term co-morbidities and biochemical data between patients with adrenal incidentaloma and ‘autonomous cortisol secretion’ who were treated surgically and conservatively.Methods: The research of the database of the patients with adrenal incidentaloma diagnosed between 2007 and 2014 was performed. Among them, 43 patients with ‘autonomous cortisol secretion’ were identified and invited for a f...

Craniopharyngeoma patients have reduced quality of life and increased cardiovascular mortality because of severe obesity present in about 50% of patients. In the present study we analysed postoperative body mass index (BMI) in craniopharyngeoma patients depending on the presence of the diabetes insipidus (DI).We retrospectively analyzed 19 craniopharyngeoma patients (male:female=12:7, age 31.2 years, range 9–67) treated at our Department since 2001....

Accurate assessment of the hypothalamic–pituitary–adrenal (HPA) axis is important for the appropriate management of patients with pituitary tumours after transsphenoidal surgery. The aim of our study was to evaluate the clinical relevance of the early postoperative basal cortisol level in assessing postoperative HPA axis function. We performed a retrospective analysis of 68 patients (male:female=36:32, age 59.5 years, range 21–77) treated by transsphenoidal surg...

Introduction: The study was designed to assess the effects of remission of acromegaly on bone turnover.Methods: Twenty-eight patients with active acromegaly (14 women; age 48.0±9.8 years) were enrolled in the study. The control group comprised 28 age- and sex-matched healthy individuals. Bone turnover markers (osteocalcin, β-crosslaps, and bone alkaline phosphatase) were measured at enrolment and 6 months after achievement of disease remission....

Craniopharyngiomas are rare and histologically benign tumors that are associated with an unfavourable prognosis and controversial optimal treatment. The aim of this retrospective study was to review clinical presentation, natural history and therapeutic outcomes of patients with craniopharyngiomas treated in a single center between 1995 and 2017. In that period, 38 patients (16 children and 22 adults) were diagnosed with craniopharyngioma. Median age at the time of diagnosis i...

Background: Pituitary apoplexy is a rare complication of pituitary adenomas, especially nonfunctioning tumors. It is associated with severe headache, which may be accompanied by visual disturbances or ocular palsy. Here we present two patients who suffered from pituitary adenoma apoplexy while receiving anticoagulation therapy with non-vitamin K antagonists.Case presentation: A 74-year old woman was diagnosed with a non-functioning pituitary macroadenoma...

Background: Measurement of the peripheral cortisol concentration is necessary for calculating selectivity ratio (SR) based on which is AVS success evaluated.Objective: The goal of this study was to assess the necessity for two peripheral cortisol measurements in sequential AVS, one after cannulation of the adrenal vein on one side, and the second after cannulation on the other side.Methods: This retrospective study included 142 bil...

Objective: Patients with Cushing syndrome (CS) have impaired health-related quality of life (HRQoL) before and after surgery. The data on the optimal hydrocortisone dose after surgical cure of CS is scarce. Therefore, we investigated the influence of hydrocortisone dose on HRQoL after surgical treatment of CS. We hypothesized that patients who receive higher hydrocortisone doses after surgery would have better HRQoL and fewer cortisol withdrawal symptoms.<p class="abstext"...