Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep253 | Calcium and Vitamin D metabolism | ECE2015

TSH and free-T3 correlate negatively and independently with bone mineral density in adults with subclinical hypothyroidism

de Lloyd Anna , Muller Ilaria , Dodd Alan , Durrant Hilary , Pettit Rebecca , Darlington Sarah , Zhang Lei , Evans Carol , Rees Aled , Ludgate Marian

The role of the thyrotropin receptor (TSHR) in bone is unclear. TSHR-deficient mice have low bone mineral density (BMD) and focal osteosclerosis despite normal thyroid hormones (suggesting TSHR function, in bone, is important). Subclinical hypothyroidism (SH) has various aetiologies including thyroid autoimmunity (TA) and inactivating TSHR mutations (TSHR-M). In TSHR-deficiency & TSH-M elevated TSH compensates for reduced TSHR function, whereas in TA it compensates for red...