Searchable abstracts of presentations at key conferences in endocrinology

ea0028p334 | Thyroid | SFEBES2012

PBF is a novel regulator of the thyroid hormone transporter MCT8

Smith Vicki , Read Martin , Lewy Gregory , Fong Jim , Seed Robert , Sharma Neil , Kwan Perkin , Ryan Gavin , Darras Veerle , Boelaert Kristien , Franklyn Jayne , McCabe Christopher

Within the basolateral membrane of thyroid follicular epithelial cells, two transporter proteins are important for thyroid hormone (TH) biosynthesis. Initially, sodium iodide symporter (NIS) delivers iodide from the bloodstream into the thyroid and, following biosynthesis, monocarboxylate transporter 8 (MCT8) mediates secretion of TH from the thyroid gland. NIS-mediated radioiodine uptake is also critical in the treatment of thyroid tumours and metastases. We have previously d...