Searchable abstracts of presentations at key conferences in endocrinology

ea0011p92 | Clinical case reports | ECE2006

Purely adrenaline-secreting phaeochromocytoma: a classical presentation of a rare entity

Merghani A , Darzy KH , Morris D , Carpenter R , Deaner A , Monson JP

A provisional diagnosis of paroxysmal atrial fibrillation with normal blood pressure and echocardiogram was made in a 58 years old man. He described ‘funny turns’ on standing during which he would become sweaty, tremulous with palpitations and headache and facial flushing preceded by pallor. The patient was otherwise fit and healthy with a BMI of 27.3 kg/m2; he used to drink about 15 pints of beer per week and smoke 11 cigarettes daily for the last 40 year...

ea0011p58 | Clinical case reports | ECE2006

Surgical management of metastatic phaeochromocytoma: review of 2 cases

El-Tawil TH , Darzy KH , Carpenter R , Bhattacharya S , Edmondson S , Monson JP

We report two cases of MIBG avid secretory phaeochromocytoma in 2 middle-aged ladies. Adrenalectomy, after standard preparation, was performed successfully and histology confirmed complete excision of a phaeochromocytoma in both cases; however, there was capsular infiltration and metastasis to a neighboring lymph node in the first case. In this case, surveillance CT scans 3 and 6 months later showed left adrenal bed recurrence and rapidly growing lesions in the right lobe of t...

ea0011p578 | Neuroendocrinology and behaviour | ECE2006

The impact of hypothalamic-pituitary (h-p) irradiation on the TSH Bio/Immuno (B/I) ratio in the fed and fasting states

Darzy KH , Persani L , Borgato S , Beck-Peccoz P , Shalet SM

The TSH B/I ratio is normally reduced overnight and is substantially reduced in patients with overt central hypothyroidism due to h-p axis tumours before and after treatment. It is unknown if similar changes in the TSH B/I ratio in the absence of overt central hypothyroidism contribute to the increased TSH levels seen in cancer survivors who undergo h-p axis irradiation. Thus, we selected 9 patients with the highest TSH levels out of a previously reported cohort of 37 euthyroi...

ea0011p583 | Neuroendocrinology and behaviour | ECE2006

Spontaneous GH secretion in the fed and fasting states in cranially irradiated adult cancer survivors with normal peak GH responses to two provocative tests: does GH neurosecretory dysfunction exist?

Darzy KH , Murray RD , Gleeson HK , Pezzoli SS , Thorner MO , Shalet SM

A few studies have suggested that radiation-induced growth hormone neurosecretory dysfunction (GHNSD) exists in children irradiated for leukemia (18–24 Gy). The presence or absence of GHNSD in adult cancer survivors has not been studied before. Thus, 24-hour spontaneous GH secretion was studied by 20 min sampling both in the fed state (n=16; 6 women) and the last 24 hours of 33-hour fast (n=10; 3 women) in adult cancer survivors, of normal GH status defined ...