Endocrine Abstracts

PurposeThere is a continuity of changes ranging from enterochromaffin‐like (ECL) cell hyperplasia to type 1 gastric neuroendocrine neoplasms (GNEN1) with important clinical implications. Although the effect of the circadian clock system on tumorigenesis has been addressed, the role of the peripheral clock system in the transition from ECL-cell hyperplasia to GNEN1 remains to be explored.MethodsSix patie...

Background: Gastric neuroendocrine tumors (g-NETs) type I are increasingly recognized and are usually well-differentiated grade 1 neoplasms. However, rare cases of metastatic spread and adverse prognosis have been described in the literature.Aims: The aim of this study was to evaluate the characteristics and the natural history of grade 2 g-NETs type I.Materials and Methods: We collected retrospectively the data of patients with g-...

Introduction: Gastric neuroendocrine tumors (GNET) are rare gastric neoplasms which are developed due to hypergastrinemia and enterochromaffin-like (ECL) cell hyperplasia. Although the effect of the circadian clock system disruption on tumorigenesis has been already studied in various malignancies and autoimmune diseases, the role of the peripheral clock system in the transition from ECL-cell hyperplasia to GNEN1 (Type 1 Gastric Neuroendocrine Neoplasms) remains unexplored.</p...

Introduction: A change in the biological behaviour of Small-Intestinal Neuroendocrine Tumours (SiNETs), as reflected by an increase in the Ki-67 proliferation index may occur over time. The purpose of this study was to evaluate longitudinal changes in Ki-67 indices of SiNETs and assess the impact of these in overall survival (OS).Patients and methods: We screened 551 patients with SI-NETs diagnosed from 1993, through 2021, identified using the SI-NET dat...