Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep555 | Pituitary and Neuroendocrinology | ECE2021

Abberant expression pattern of circadian clock genes in Type 1 gastric neuroendocrine neoplasms compared to ECL hyperplasia

Karapanagioti Angeliki , Daskalakis Kosmas , Nasiri-Ansari Narjes , Vlachou Erasmia , Kyriakopoulos Georgios , Kassi Evanthia , Kaltsas Gregory

PurposeThere is a continuity of changes ranging from enterochromaffin‐like (ECL) cell hyperplasia to type 1 gastric neuroendocrine neoplasms (GNEN1) with important clinical implications. Although the effect of the circadian clock system on tumorigenesis has been addressed, the role of the peripheral clock system in the transition from ECL-cell hyperplasia to GNEN1 remains to be explored.MethodsSix patie...

ea0099ep546 | Endocrine-Related Cancer | ECE2024

Grade 2 gastric neuroendocrine tumours type 1: not always an indolent disease

Tsoli Marina , Panagaki Maria , Ioannidou Katerina , Karapanagioti Aggeliki , Daskalakis Kosmas , Kaltsas Gregory

Background: Gastric neuroendocrine tumors (g-NETs) type I are increasingly recognized and are usually well-differentiated grade 1 neoplasms. However, rare cases of metastatic spread and adverse prognosis have been described in the literature.Aims: The aim of this study was to evaluate the characteristics and the natural history of grade 2 g-NETs type I.Materials and Methods: We collected retrospectively the data of patients with g-...

ea0081p422 | Pituitary and Neuroendocrinology | ECE2022

Aberrant expression of clock genes in human gastric neuroendocrine tumors type 1

Karapanagioti Angeliki , Nasiri-Ansari Narjes , Daskalakis Kosmas , Vlachou Erasmia , Kyriakopoulos Georgios , Randeva Harpal , Kaltsas Gregory , Kassi Eva

Introduction: Gastric neuroendocrine tumors (GNET) are rare gastric neoplasms which are developed due to hypergastrinemia and enterochromaffin-like (ECL) cell hyperplasia. Although the effect of the circadian clock system disruption on tumorigenesis has been already studied in various malignancies and autoimmune diseases, the role of the peripheral clock system in the transition from ECL-cell hyperplasia to GNEN1 (Type 1 Gastric Neuroendocrine Neoplasms) remains unexplored.</p...

ea0099p104 | Pituitary and Neuroendocrinology | ECE2024

Increment in KI-67 proliferation indices over time is associated with worse survival outcomes in small-intestinal neuroendocrine tumours

Daskalakis Kosmas , Tsoli Marina , Wallin Goran , Kogut Angelika , Srirajaskanthan Rajaventhan , Harlow Christopher , Giovos Georgios , Weickert Martin , Kos Kudla Beata , Kaltsas Gregory

Introduction: A change in the biological behaviour of Small-Intestinal Neuroendocrine Tumours (SiNETs), as reflected by an increase in the Ki-67 proliferation index may occur over time. The purpose of this study was to evaluate longitudinal changes in Ki-67 indices of SiNETs and assess the impact of these in overall survival (OS).Patients and methods: We screened 551 patients with SI-NETs diagnosed from 1993, through 2021, identified using the SI-NET dat...