Searchable abstracts of presentations at key conferences in endocrinology

ea0078p60 | Pituitary and Growth | BSPED2021

Abnormalities of growth hormone secretion in lowe syndrome: a case series

Pattani Nikhil , Dastamani Antonia , Gan Hoong-Wei , Dattani Mehul

Background: Lowe Syndrome is an X-linked recessive genetic disorder caused by OCRL gene mutations, which impair intracellular trafficking processes. Signs are multisystemic, including congenital cataracts, intellectual disability and proximal renal tubulopathy. Short stature is a common association, often attributed to chronic kidney disease through childhood. However, recent evidence suggests that the hypothalamo-pituitary-somatotroph axis may play a role. <p class="abste...

ea0051p041 | Pituitary and growth | BSPED2017

ACTH deficiency and potential for reversibility in children and young people (CYP) with craniopharyngioma

Pieri Kyriaki , Michaelidou Maria , Dastamani Antonia , Spoudeas Helen A.

Introduction: ACTH deficiency is life-threatening, but difficult to differentiate from ACTH suppression especially in children and young people (CYP) receiving perioperative corticosteroids for pituitary tumour surgery. In our experience, ACTH is the most, and GH the least robust anterior pituitary hormone, with LH/FSH and TSH intermediate in hierarchical loss.Aims: To assess potential misdiagnosis of ACTH suppression versus deficiency and time to adrena...

ea0051p035 | Miscellaneous/other | BSPED2017

Post-prandial hyerinsulinaemic hypoglycaemia post-esophageal surgery in children

Malhotra Neha , Dastamani Antonia , Guemes Maria , Gilbert Clare , Ress Clare , Dattani Mehul , Shah Pratik

Introduction: Post-prandial hyerinsulinaemic hypoglycaemia (PPHH) or dumping is a recognized complication of various gastric surgeries. There are very few paediatric case reports to confirm PPHH post esophageal repair. We here report two cases who presented with dumping syndrome after a variable time period post esophageal atresia repair and response to medications.Case 1: A 6 month old female diagnosed with Wolf-Hirschhorn syndrome, born at 38+3 weeks b...

ea0037ep616 | Obesity and cardiovascular endocrinology | ECE2015

A low glycaemic index, low glycaemic load snack based on stevia and fortified with vitamin D, improves metabolic/hormonal profile, and compliance in normal subjects and prediabetics; results from a 4 months, controlled trial

Livadas Sarantis , Dastamani Antonia , Stefanaki Charikleia , Mantzou Emily , Painesi Areti , Papanikolaou Eleni , Chrousos George

Introduction: Half of subjects following a low-calorie dietary program cannot tolerate its nutritional restrictions and abandon it. A realistic approach to overcome this obstacle is the addition of low glycaemic index (GI), low glycaemic load (GL) snacks in their nutrition. Stevia, a potent, low calorie natural sweetener exerts anti-hyperglycaemic and insulinotropic activities. Furthermore, Vitamin D deficiency may affect diabetes development in the long run.<p class="abst...

ea0058oc4.7 | Oral Communications 4 | BSPED2018

Clinical outcomes of focal congenital hyperinsulinism – a UK perspective

Dastamani Antonia , Yau Daphne , Gilbert Clare , Morgan Kate , O'Shea Elaine , Pimlott Helen , DeCoppi Paolo , Craigie Ross , Flanagan Sarah , Houghton Jayne , Senniappan Senthil , Didi Mohammed , Banerjee Indi , Shah Pratik

Background: The focal type of Congenital Hyperinsulinism (CHI) is characterized by a cluster of abnormal insulin over-secreting β-cells within a restricted area of the pancreas. Early identification and intervention of the focal lesion is critical in CHI management, preventing both acute and chronic complications.Objective: The purpose of this study is to review outcomes of treatment response in focal CHI.Design: Retr...

ea0058oc5.9 | Oral Communications 5 | BSPED2018

Diazoxide-induced pulmonary hypertension: UK multicentre retrospective study on the risk factors, monitoring approach andmanagement recommendations

Ching Chen Suet , Dastamani Antonia , Pintus Donatella , Yau Daphne , Aftab Sommayya , Bath Louise , Swinburne Craig , Hunter Lindsey , Giardini Alessandro , Christov Georgi , Senniapan Senthil , Banerjee Indraneel , Shaikh Guftar , Shah Pratik

Objectives: Diazoxide is first line treatment for hypoglycaemia due to hyperinsulinaemic hypoglycaemia (HH). Although sporadic cases of pulmonary hypertension (PH) have been reported, no HH cohort has been systematically characterised to understand severity and risk factors for diazoxide-induced PH.Methods: To investigate the onset, progress and associated factors in PH, patients with HH who developed diazoxide-induced PH in 4 regional centres were retro...