Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

Published by BioScientifica

Page 1 of about 104 results

ea0066in1.2 | (1) | BSPED2019

Dattani Mehul

Mehul Dattani is Professor of Paediatric Endocrinology based at the University College London (UCL) Great Ormond Street Institute of Child Health, and Specialty Lead in Endocrinology at Great Ormond Street Hospital for Children (GOSH). He has an active clinical practice in paediatric and adolescent Endocrinology at GOSH and University College London Hospitals (UCLH). He completed a 3-year term as Chair of the British Society for Paediatric Endocrinology and Diabetes, followed ...
shares

ea0039symp1.2 | Industry sponsored Satellite Symposium | BSPED2015

Novel insights into pituitary dysfunction - Congenital hypopituitarism: new genes, new phenotypes

Dattani Mehul

Congenital hypopituitarism (CH) is a rare but life-threatening condition that is associated wth significant morbidity and mortality. It occurs in 1 in 4000 to 1 in 10000 live births, and may present variably. In the newborn period it is associated with conjugated hyperbilirubinaemia, micropenis with undescended testes in affected males, hypoglycaemia and possibly features of hypothyroidism including lethargy and feeding difficulties. Later on, it may present with early growth ...
shares

ea0030s1 | CME TRAINING DAY | BSPED2012

Physiology and developmental disorders of the pituitary

Dattani Mehul

The pituitary gland is a central regulator of growth, homeostasis and reproduction. It is in turn regulated by the hypothalamus, which generates a number of releasing factors (GHRH, TRH, GnRH, CRH) and the inhibitory hormone somatostatin. The pituitary gland consists of the anterior and posterior lobes, both of which have separate developmental origins. The anterior lobe derives from the oral ectoderm, whilst the posterior lobe derives from the neuroectoderm. The anterior pitu...
shares

ea0023s4 | (1) | BSPED2009

Investigating peripubertal growth problems

Dattani Mehul

The investigation of growth failure can be fraught with difficulties at all ages, but never more so than in the peri-pubertal period. The differential diagnosis at this period of life includes constitutional delay of growth and puberty (CDGP), hypogonadotrophic hypogonadism (HH), GH insufficiency (GHD/GHI) and a physiological peri-pubertal reduction in growth velocity in addition to other organic causes of growth failure. Careful auxology and pubertal staging with assessment o...
shares

ea0016s23.1 | Towards a better understanding of hypothalamic–pituitary disorders | ECE2008

Pituitary development and congenital hypopituitarism (CH)

Dattani Mehul

Normal hypothalamo-pituitary development is critically dependent upon a complex genetic cascade that dictates organ commitment, cell differentiation, and cell proliferation within the anterior pituitary. Mutations in a number of transcription factors have been implicated in the aetiology of congenital hypopituitarism (CH) in mice and humans; resulting phenotypes and their inheritance may be highly variable. Mutations in genes implicated in early pituitary development may be as...
shares

ea0036P79 | (1) | BSPED2014

UK GH stimulation test survey

Chesover Alexander , Dattani Mehul

Background: Previous studies show poor consensus on the use of GH stimulation tests. Sex steroid priming and re-testing in the transition period are areas not previously surveyed. In light of more recent guidance and expert opinion, this survey aims to analyse the diagnostic processes employed in the diagnosis of GH deficiency (GHD) in the UK.Methods: Data were collected from tertiary paediatric endocrinologists, paediatricians with a specialist interest...
shares

ea0033p71 | (1) | BSPED2013

GH neurosecretory dysfunction may be associated with structural abnormalities of the hypothalamic–pituitary axis

Hughes Claire , Dattani Mehul

Introduction: GH neurosecretory dysfunction (NSD) refers to children with abnormal auxology, normal GH responses to provocative testing, but with impaired spontaneous GH secretion over 24 h, leading to low IGF1 concentrations. It is thought to be due to abnormal hypothalamic function with aberrant GHRH and somatostatin secretion leading to impaired GH secretion and subsequently suboptimal growth.Methods: We reviewed children admitted for spontaneous GH s...
shares

ea0033p81 | (1) | BSPED2013

The role of GH in early postnatal life in mice

Gevers Evelien , Dattani Mehul

GH concentrations are high at birth but it is unclear whether and where GH signaling takes place at this time. We assessed the response to GH in young normal and GH-deficient (GHD) pups.Transgenic M2-GRF mice were significantly GHD from birth. Weight and plasma IGF1 concentration were normal, but reduced at 6–8 day of age (P<0.01). 3 and 10-day-old GHD and normal (WT) mice were treated with bovine GH (bGH, 10 μg/g bw s.c. bd) or ve...
shares

ea0051p026 | Miscellaneous/other | BSPED2017

Albright’s Hereditary Osteodystrophy associated with resistance to insulin and thyroid hormone in three male siblings

MacGloin Helen , Rangasami Jayanti , Dattani Mehul

Introduction: Pseudohypoparathyroidism Type 1a (PHP1a) is a rare disorder caused by mutation in GNAS, which encodes the alpha-subunit of the trimeric stimulatory G protein, Gsα, and links numerous G protein-coupled receptors (GPCR) to adenylyl cyclase. GPCRs are crucial for intracellular endocrine signalling, and since GNAS is expressed predominantly from the maternal allele in some tissues, maternally inherited loss of function GNAS mutations are associated with...
shares

ea0066p75 | Pituitary | BSPED2019

Growth and growth hormone abnormalities in bartter syndrome types 3 and 4

Prentice Philippa , Bockenhauer Detlef , Dattani Mehul

Introduction: Bartter Syndrome types 3 and 4 (BS3/4) are rare tubulopathies, caused by CLCNKB and BSND mutations, which affect chloride channel function in the loop of Henle and distal convolute. Historically, with late presentation and poor disease control, patients had severe short stature. Multiple case reports have also found associations between BS3/4 and Growth Hormone deficiency (GHD). Our aim was to investigate growth and presence of GHD in a large co...
shares

Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2023 | Privacy policy | Cookie settings

BiosciAbstracts

Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.

Find out more