Searchable abstracts of presentations at key conferences in endocrinology

ea0019p317 | Steroids | SFEBES2009

Cofactors and modify Cofactors and modifications of the glucocorticoid receptor

Davies L , Gkourtza A , Symeou C , Lynch J , Taylor S , Demonacos C , Krstic-Demonacos M

The glucocorticoid receptor (GR) is a member of the nuclear hormone receptor superfamily that acts as a hormone responsive transcription factor. GR function is controlled by hormone binding, post-translational modifications and through interaction with cofactors. Here, we report that JNK dependent phosphorylation of GR affects its sumoylation. JNK activation by UV radiation that targets GR for phosphorylation at serine 246 (S246) facilitated subsequent GR sumoylation at lysine...

ea0003oc33 | Hormone Action | BES2002

The role of the PPAR gamma in thyroid eye disease: Possible contra-indication for thiazolidenedione therapy

Starkey K , Heufelder A , Evans L , Davies J , Baker G , Ludgate M

A male patient treated with a thiazolidenedione (TZD) PPAR gamma agonist for Type 2 diabetes had a dramatic worsening of his thyroid eye disease (TED), which had been stable and inactive for more then two years. Expansion of the orbital fat seemed to be the underlying cause and we have investigated the effects of a PPAR gamma agonist (and subsequently an antagonist) on the adipogenesis of preadipocytes from 10 different patients, representing several fat depots, including TED ...