Searchable abstracts of presentations at key conferences in endocrinology

ea0059p101 | Diabetes & cardiovascular | SFEBES2018

Characterisation of diabetes mellitus in turner syndrome – Turner syndrome life course project

Pimblett Antoinette Cameron , Nair Sasha , La Rosa Clementina , Davies Melanie C , Conway Gerard S

Introduction: Diabetes Mellitus (DM) is 2–4 times more common in Turner Syndrome (TS) than karyotype normal females. Diagnosis of DM in TS is usually based on age of presentation and insulin dependency without regard for DM- autoimmunity. Previous research has identified DM associations with the isochromosome and ring chromosome. However, only small numbers of diabetics have been included in reports so far. Here we present preliminary data on DM characterisation in TS.</p...

ea0044oc2.3 | Neuroendocrinology and Reproduction | SFEBES2016

Associations between karyotype and long term health outcomes in adults with Turner Syndrome; The Turner Syndrome Life Course Project

Cameron- Pimblett Antoinette , La Rosa Clementina , King Thomas , Lioa Lih-Mei , Davies Melanie C , Conway Gerard S

Background: Turner syndrome (TS) comprises a group of sex chromosome anomalies affecting approximately 15,000 in the UK. TS affects every organ system in the body through haploinsufficiency of genes that are normally expressed by both X chromosomes. Common features include short stature, congenital heart diease and gonadal dysgenesis requiring long-term oestrogen replacement but the adult phenotype extends to excess risk of diabetes, hypertension and hepatosteatosis. UCLH has ...

ea0059p054 | Bone and calcium | SFEBES2018

Risk of bone fracture is not increased in women with TS compared to women with ovarian failure

Pimblett Antoinette , Elliot Jessica , Wilson Jack , Nair Sasha , La Rosa Clementina , Davies Melanie C , Conway Gerard S

Women with Turners Syndrome (TS) have been shown to have reduced bone mineral density (BMD) but there is uncertainty about how this relates to fracture risk. The little data that does exist is conflicting, with one case series finding no difference compared to controls and one survey suggesting an increased risk of fracture particularly of the forearm. Proposed mechanisms for reduced BMD include short stature, oestrogen deficiency and bone dysplasia. In addition, fracture risk...

ea0073oc4.4 | Oral Communications 4: Reproductive and Developmental Endocrinology | ECE2021

Fertility outcomes in women with hypopituitarism compared to women with hypogonadotrophic hypogonadism in a single UK centre

Attard Carol Cardona , O’Donovan Oliver , Nair Sasha , Puri Davina , Talaulikar Vikram S , Davies Melanie C , Conway Gerard S

ObjectivePrevious studies have documented poor fertility results in women with hypopituitarism (HP) both in terms of pregnancy rates and outcomes. We aimed to assess ovulation induction (OI) and pregnancy outcomes in women with HP compared to women with hypogonadotrophic hypogonadism (HH) treated at University College London Hospitals.DesignA retrospective study.Patients<p class="ab...

ea0059p197 | Reproduction | SFEBES2018

Reproductive Life Course Project: Preliminary data from UK Turner Syndrome Pregnancy audit

Burt Elizabeth , Pimblett Antoinette Cameron , Donohoe Mollie , Calanchini Matilde , Morton Claire , Smyth Arlene , Brooke Antoinia , Gleeson Helena , Simpson Helen , Turner Helen E , Davies Melanie C , Conway Gerard S

Turner Syndrome (TS) affects 1:2500 females and is caused by the partial or complete loss of one X chromosome. About 80% of women with TS experience primary amenorrhea and therefore the only option for fertility treatment is ovum donation (OD). The remaining 20% may have the opportunity for a spontaneous pregnancy. Pregnancy in women with TS has been associated with excess obstetric risk such as miscarriage and hypertension. Maternal mortality has been estimated to be 2% risk ...