Searchable abstracts of presentations at key conferences in endocrinology

ea0038p140 | Growth and development | SFEBES2015

Hormonal control of β-cell proliferation in fetal ovine pancreatic islets in vitro

Harris Shelley E , Kelly Amy , Davis Melissa A , Anderson Miranda , Forhead Alison J , Limesand Sean W

Hormonal control of pancreatic β-cell development in the fetus during late gestation remains unclear. In fetal sheep hypothyroidism causes an increase in pancreatic β-cell mass in association with increased plasma insulin and leptin concentrations. This study investigated the effects of triiodothyronine (T3), insulin and leptin on proliferation rates in fetal ovine pancreatic β-cells in vitro.All procedures were approve...