Searchable abstracts of presentations at key conferences in endocrinology

ea0063mte1 | (1) | ECE2019

The road from flash glucose monitoring to hybrid closed loop systems: keys to success.

De Block Christophe

Living with type 1 diabetes (T1D) is challenging and requires intensive glucose monitoring and titration of insulin in order to obtain near-normal glucose levels to reduce the risk of complications. However, changes in dietary intake and level of activity can cause large glucose excursions. Continuous glucose monitoring systems, either intermittently scanned either real-time, can provide a comprehensive picture of glucose profiles, allowing patients to make therapeutic adjustm...

ea0090p677 | Pituitary and Neuroendocrinology | ECE2023

The diagnostic accuracy of dex-CRH test in differentiating between Cushing’s disease and pseudo-Cushing syndrome. A single-center experience

De Herdt Carlien , Dirinck Eveline , Eva Philipse , De Block Christophe

Background: Distinguishing pseudo-Cushing syndrome (PCS) from mild forms of Cushing’s disease (CD) is a challenge. The dexamethasone-Corticotropin Releasing Hormone test (dex-CRH) assumes that cortisol response to CRH is preserved in CD while suppressed in PCS after the low dose dexamethasone suppression test (LDDST). Methods: Persons with a suspicion of CD based on mild clinical features and a positive first-line screening test were included. They ...

ea0099ep962 | Endocrine-Related Cancer | ECE2024

Non-islet cell tumor hypoglycemia

Van Mieghem Eugenie , Mazlom Hadi , Clinck Isabel , De Block Christophe

Introduction: A rare cause of hypoglycemia is non-islet cell tumor hypoglycemia (NICTH), a paraneoplastic syndrome caused by tumoral overexpression of insulin-like growth factor 2 (IGF-2) and pro-IGF-2.Case presentation: : A 57-year old woman presented with odd behavior each morning that improved after breakfast and extensive weight loss (13 kg in 3 years). The patient was hypoglycemic (2.6 mmol/l) with low insulin levels (<1.39 pmol/l) and C-peptide...

ea0081rc10.1 | Rapid Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Insulin resistance as indexed by the estimated glucose disposal rate and liver fat content are correlated in type 1 diabetes

Mertens Jonathan , Spinhoven Maarten , Dirinck Eveline , Vonghia Luisa , Francque Sven , De Block Christophe

Introduction: The prevalence of metabolic syndrome is increasing in individuals with T1D, which could potentiate the development of NAFLD. The pathophysiology of NAFLD in T1D is still unclear, due to the co-existence of predisposing and protective factors. Insulin resistance (IR) is theorized as a key driver of NAFLD.Aim: We investigated the association between liver fat content (LFC), NAFLD, and IR in individuals with T1D. Subjects underwent magnetic re...

ea0081ep88 | Adrenal and Cardiovascular Endocrinology | ECE2022

Management of primary hyperaldosteronism and the role of adrenal venous sampling; a single-center experience

De Herdt Carlien , Eva Philipse , Olivier D'Archambeau , Dirk Ysebaert , Annemiek Snoeckx , Bart Peeters , De Block Christophe

Background: Primary hyperaldosteronism (PA) is a prevalent, but underdiagnosed syndrome. Diagnosis and treatment have been relatively constant since the development of the latest Endocrine Society guidelines in 2016.Study objective: Baseline characteristics, treatment and follow-up of subjects with PA referred for adrenal venous sampling (AVS) in a tertiary hospital since 2009 are presented.Results: Thirty five subjects (M/F: 17/18...

ea0073aep203 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Is there an association between sex steroids and biopsy-proven non-alcoholic fatty liver disease in obese men? A cross-sectional analysis of 134 men

Herdt Carlien De , Block Christophe De , Kristof Van Dessel , An Verrijken , Francque Sven , Dirinck Eveline

Background and aimsLow levels of testosterone and non-alcoholic fatty liver disease (NAFLD) in obese men are both linked to the metabolic syndrome, but the independent association between testosterone and NAFLD needs to be elucidated. In this cross-sectional analysis the association between total testosterone (total T) and calculated free testosterone (cFT) on the one hand and NAFLD, non-alcoholic steatohepatitis (NASH) and fibrosis on the other hand was...

ea0075o03 | Obesity, metabolism &amp; miscellaneous endocrinology | EYES2021

The estimated glucose disposal rate as a potential biomarker for non-alcoholic fatty liver disease and cardiovascular disease in type 1 diabetes

Mertens Jonathan , Weyler Jonas , Vonghia Luisa , Dirinck Eveline , Francque Sven , De Block Christophe

Background: Patients with type 1 diabetes (T1D) have an increased risk of cardiovascular disease (CVD), despite insulin therapy. Insulin resistance is strongly associated with non-alcoholic fatty liver disease (NAFLD) and CVD. The euglycemic clamp, the gold standard to assess insulin resistance in T1D, is unsuited for clinical practice. The estimated glucose disposal rate (eGDR) is increasingly used as an alternative in T1D, but its role as a NAFLD or CVD predictor is unexplor...

ea0099oc4.3 | Oral Communications 4: Diabetes, Obesity, Metabolism and Nutrition | Part I | ECE2024

Nitrate-mediated dilation is impaired in people with type 1 diabetes and co-existent metabolic dysfunction-associated steatotic liver disease

Mertens Jonathan , Stoop Tibor , Francque Sven , De Block Christophe , Heuten Hilde

Introduction: The risk of cardiovascular disease (CVD) is increased in type 1 diabetes (T1D). Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to CVD, but evidence hereof is limited in people with T1D. Endothelial dysfunction is currently considered a key early event in the atherosclerotic process, but is never determined in people with T1D and co-existent MASLD.Methods: We measured flow-mediated dilation (FMD) and nitrate-media...

ea0084ps2-10-94 | Nodules & Cancer | ETA2022

Follow-up and incidence of malignancy in eu-tirads 3 nodules with indication of fine needle aspiration cytology. a single-center descriptive study

de Herdt Carlien , Peiffer Frida , Nicolay Simon , Delrue Frank , Pauwels Patrick , Ysebaert Dirk , De Greef Kathleen , De Block Christophe

Background: Current guidelines recommend repeat evaluation of a benign thyroid nodule after 1 to 2 years, which is only based on expert opinion. Objective data are needed to evaluate this recommendation.Methods: This is a retrospective, descriptive study to describe the follow-up and incidence of malignancy in EU-TIRADS 3 nodules for which a fine needle aspiration cytology (FNAC) was indicated between 2017 and 2022. PET-positive thyroid nodules and thyro...

ea0063p428 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

PAI-BEL: the Belgian registry on Primary Adrenal Insufficiency

Driessens Natacha , Corvilain Bernard , De Block Christophe , T'Sjoen Guy , Nobels Frank , Ghys Christophe , Vroonen Laurent , Maiter Dominique

Introduction: Primary Adrenal Insufficiency (PAI or Addison’s disease) is a rare disease with an increasing prevalence that may be complicated by life-threatening acute adrenal crisis. Valid epidemiological data are difficult to obtain. In Belgium, a national PAI registry had not been established yet.Objective: We collected epidemiological and clinical data in a large cohort of adult patients with a known Addison’s disease to have a better know...