Searchable abstracts of presentations at key conferences in endocrinology

ea0016p620 | Reproduction | ECE2008

Basal INSL3 levels predict LH and androgen response to GnRH analogue in PCOS women

Patton Laura , Gambineri Alessandra , De Iasio Rosaria , Fanelli Flaminia , Pasquali Renato

In a previous study, we demonstrated that the concept of functional ovarian hyperandrogenism (FOH), as documented by the exaggerated 17OHP response to buserelin (GnRH-analogue) does not represent a specific feature of all women with PCOS, being present in less than half of PCOS and is a condition characterized by more severe hyperandrogenemia, glucose-stimulated B-cell insulin secretion and worse insulin resistance. INSL3 is produced in the Leydig cells and at reduced levels i...

ea0016p550 | Obesity | ECE2008

Endocrine and metabolic alterations in narcoleptic patients as result of orexin-A reduction

Dalmazi Guido , Poli Francesca , Ribichini Danilo , Fanelli Flaminia , Vicennati Valentina , de Iasio Rosaria , Montagna Pasquale , Pasquali Renato , Plazzi Giuseppe , Pagotto Uberto

Aims: Narcolepsy with cataplexy (NC) is a rare, chronic disease, characterized by excessive daytime sleepiness, cataplexy, disrupted nocturnal sleep and manifestations of abnormal REM (Rapid Eye Movement) sleep. Human NC is probably caused by environmental and genetic factors, leading to dysfunctions in hypothalamic orexigenic neurons. Recent studies showed that NC was associated with an increase in Body Mass Index, despite a reduction in food intake. In the current study we i...