Endocrine Abstracts

Background: Up to 30% of incidentally-discovered adrenal masses are lipid-poor adenomas (LPA). The clinical significance of LPA is poorly understood. The aim of the study was to investigate histopathological features of LPA and their association with radiological parameters.Methods: A total of 39 patients with radiological evidence of LPA were included. LPA was defined as an adrenal mass with pre-contrast Hounsfield units (HU) ≧10, associated wit...

Background: Adrenal lipid poor adenoma (LPA) and adrenocortical cancer (ACC) may overlap in computerized tomography (CT). Radiomics recently emerged as new tool for malignant behavior identification.Aim: To assess radiomics utility for identification of ACC and LPA in adrenocortical masses with unenhanced (UE) CT scan attenuation≥10 Hounsfield Unit (HU).Methods: We retrospectively enrolled 50 patients, 38 radiologically defin...

Background: Adrenal endothelial tumors are mainly represented by adrenal cavernous hemangiomas (ACHs) and adrenal cystic lymphangiomas (ACLs). They are rare incidental findings, with about 160 cases of both ACHs and ACLS reported in the literature. They are usually unilateral, benign, non-functioning, and asymptomatic, although abdominal pain and life-threatening retroperitoneal hemorrhage may occur if tumor size increases. Radiological features often overlap with malignant ad...

Introduction: Differentiated thyroid cancers (DTCs) carrying BRAF and TERT mutations are associated with high-risk clinicopathological features and poor prognosis. However, there are currently no studies comparing BRAF-TERT tumors to other double mutated DTCs.Aim: To verify whether BRAF-TERT mutated DTCs differ from other double mutated DTCs in terms of clinicopathological characteristics and outcome.Materials and Methods: 168 DTCs...

Introduction: There is no clear indication for radioiodine treatment (RAI) in patients affected by differentiated thyroid cancer (DTC) in Stage I and ATA intermediate risk, according to American Thyroid Association (ATA) guidelines.Purpose: Our aim is to evaluate whether integration of BRAF status and thyroglobulin TSH-stimulated at the time of RAI (A-HTg) could further improve accuracy of stratification, and therefore therapeutic management, in DTC pati...

Background: Radiomics, or texture analysis, is gaining growing interest for its high prediction performances, mainly for clinical purposes. Radiomics application for pheochromocytoma immunohistochemistry (IHC) and molecular biology prediction is still unexplored.Aim: To evaluate radiomics ability to predict pheochromocytoma IHC.Methods: We retrospectively enrolled 38 pheochromocytoma who underwent surgery at Sant’Orsola-Malpig...

Background: Current parameters of conventional radiology have several limitations in defining the nature of adrenal masses. Radiomics, or texture analysis, has shown high diagnostic performance in recent pilot studies, although confirmatory studies are needed. Moreover, the effect of combination of radiomics with hormonal secretion on diagnostic performance is poorly explored.Aim: To evaluate the accuracy of radiomics in predicting adrenal masses nature ...