ea0032p968 | Steroid metabolism and action | ECE2013
De Naeyer Helene
, Everaert Inge
, De Spaey Annelies
, Kaufman Jean-Marc
, Taes Youri
, Derave Wim
Background: Hypogonadism in men is associated with low muscle mass and force. Although, androgen replacement is an effective therapy, it can have undesirable side effects. Identifying the androgen regulated molecular mechanisms that increase muscle mass and function could lead to the identification of novel muscle-specific therapeutic targets to improve the clinical outcomes of muscle wasting diseases. In this study, we examined in mice the effects of orchidectomy (after 1, 7 ...