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ea0016p283 | Endocrine tumours | ECE2008

Effect of treatment with depot somatostatin analogue octreotide on primary hyperparathyroidism in MEN-1 patients

Faggiano Antongiulio , Tavares Lidice , Milone Francesco , Mansueto Gelsomina , Ramundo Valeria , De Caro Maria Laura Del Basso , Lombardi Gaetano , De Rosa Gaetano , Colao Annamaria

Background: Expression of somatostatin receptor (SST) and therapy with somatostatin analogues have been scarcely investigated in parathyroid tumors.Objective: To evaluate the effects of depot long acting octreotide (OCT-LAR) on primary hyperparathyroidism in patients affected with multiple endocrine neoplasia type 1 (MEN-1).Subjects and methods: Eight patients with a genetically confirmed MEN-1 were enrolled. All patients presented...

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ea0014p168 | (1) | ECE2007

Somatostatin receptor immunohistochemistry in neuroendocrine tumors: a proposal of scoring system for clinical characterization and therapy selection

Faggiano Antongiulio , Volante Marco , Pia Brizzi Maria , La Rosa Stefano , Rapa Ida , Ferrero Anna , De Chiara Anna , Righi Luisella , Capella Carlo , De Rosa Gaetano , Dogliotti Luigi , Colao Annamaria , Papotti Mauro

Background: Typing somatostatin receptor (SSTR) expression in neuroendocrine tumors (NETs) is of relevance to target an octreotide-based diagnostic approach and treatment. The expanding use of immunohistochemistry to detect SSTR is to date not paralleled by an accurate methodological setting and standardized interpretation of the results.Objective: A multicentric study was designed to compare SSTR immunohistochemical expression with in vivo scinti...

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Endocrine Abstracts

Effect of treatment with depot somatostatin analogue octreotide on primary hyperparathyroidism in MEN-1 patients

Somatostatin receptor immunohistochemistry in neuroendocrine tumors: a proposal of scoring system for clinical characterization and therapy selection

BiosciAbstracts