ea0032p524 | Endocrine tumours and neoplasia | ECE2013
Rossi Valentina
, Visconti Daniela
, De Rosa Cristina
, Abbondanza Ciro
, Cioffi Iolanda
, De Masi Assunta
, Sinisi Antonio Agostino
Introduction: The presence of truncated variant of somatostatin receptors (SSTR) has been demonstrated in pituitary tumours. These variants seems act as dominant negative of SSTR and induce the resistance to SST analogue (SSTA) treatment. A variant of SSTR5, sst5TMD4, has been found to disrupt SST signalling in breast cancer cells. In present study, we assayed the expression of sst5TMD4 in two non-transformed epithelial prostate cell lines (EPC): EPN, derived from a normal sur...