Searchable abstracts of presentations at key conferences in endocrinology

ea0012p26 | Clinical case reports/Governance | SFE2006

Unusual causes of hypercalcaemia in a DGH

Debono M , Banerjee R

ObjectiveTo describe a few cases of patients presenting with various unusual causes of hypercalcaemia to a District General Hospital.MethodsThree case histories, including detailed results of laboratory tests, are presented, and the findings are discussed.ResultsIn the first case we describe an eighty year old patient recently started on lithium carbonate for mani...

ea0012p28 | Clinical case reports/Governance | SFE2006

Abdominal pain……don’t miss the endocrine case!!

Debono M , Banerjee R

ObjectiveTo describe two cases of patients presenting with abdominal pain to the gastroenterologists. These were diagnosed with primary hyperparathyroidism and adrenal insufficiency respectively.MethodsTwo case histories, including detailed results of laboratory tests, are presented, and the findings are discussed.ResultsWe present a 62 year old gentleman who was ...

ea0029p813 | Endocrine tumours and neoplasia | ICEECE2012

Clinical and biochemical characteristics of succinate dehydrogenase (SDH) mutation carriers

Venkataraman H. , Debono M. , Cook J. , Newell-Price J.

Background: Germline mutations in SDHB, SDHC, and SDHD cause hereditary phaeochromocytoma and paraganglioma (PGL) syndromes. The genotype-phenotype correlation of these mutations and relationship to penetrance is poor. Our objective was to assess characteristics of patients with SDH mutations seen in our dedicated multidisciplinary clinic.Methods: A retrospective observational study of patients attending from May 2005 to May 2010, approved as an institut...

ea0019p304 | Steroids | SFEBES2009

Modified-release hydrocortisone to provide circadian cortisol profiles

Debono M , Ghobadi C , Rostami-Hodjegan A , Huatan H , Campbell MJ , Newell-Price J , Darzy K , Merke DP , Arlt W , Ross RJ

Background: A basic tenet for hormone replacement is to replicate physiology but this is rarely if ever achieved. The adrenal glucocorticoid, cortisol, has a distinct circadian rhythm regulated by the brain’s central pacemaker. Loss of the cortisol circadian rhythm is associated with metabolic abnormalities, depression, fatigue and a poor health-related quality of life. Based on pharmacokinetic modelling we have developed a modified-release hydrocortisone (MR-HC) and test...