Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep219 | Bone and Calcium | ECE2020

An enlarged parathyroid gland emerging in the bed of the thyroid may mimic local recurrence in patients after total thyroidectomy for the papillary thyroid cancer: How does recovery from postsurgical hypoparathyroidism work?

Godlewska Paulina , Długosińska Joanna , Bakuła-Zalewska Elwira , Chojnowski Marek , Dedecjus Marek

Anatomical proximity, common blood supply and variability of location of the parathyroid glands make them prone to damage in the course of thyroid gland surgery. Total thyroidectomy (TT) poses a greater risk of postsurgical hypoparathyroidism (hypoPT) than a unilateral lobectomy, and neck lymph nodes dissection is an established risk factor of HypoPT. HypoPT lasting longer than 6–12 months postoperatively is considered permanent. The mechanism responsible for the recover...

ea0090ep532 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Pregnancy after exposure to GLP-1 receptor agonists. A case report and literature review

Wajtryt Olga , Dedecjus Marek

GLP-1 receptor agonists have become an important group of drugs used in the treatment of type 2 diabetes and then obesity. There are also many reports of very beneficial effects, e.g. in the treatment of polycystic ovary syndrome. Multidirectional metabolic impact, weight loss, menstrual regularity, and therefore fertility, when used in a group of young women, the possibility of pregnancy should always be taken. We present a case report of the patient which is the starting poi...

ea0056p1177 | Thyroid cancer | ECE2018

Role of the fine-needle aspiration biopsy of cervical lymph nodes with thyreoglobulin washing tests in management patients with differentiate thyroid cancer.

Galczynski Jacek , Bakula-Zalewska Elwira , Dedecjus Marek

The aim of this study was the assessment of diagnostic utility of fine-needle aspiration biopsy needle washout fluids (FNAB-Tg) in the cases of thyroid carcinoma recurrence and analysis of false-positive and false-negative results.Methods: Two hundred and fifteen FNAB-Tg samples from 201 patients with a history of differentiated thyroid carcinoma with suspicious lymph nodes were included in analysis. The wash-out of needle rinsed with 0.5ml of normal sal...

ea0049ep1435 | Thyroid (non-cancer) | ECE2017

K1 cell line in vitro: the impact of diagnostic absorbed doses from 131I

Stasiolek Mariusz , Adamczewski Zbigniew , Karwowski Boleslaw , Dedecjus Marek , Lewinski Andrzej

Background: Diagnostic whole-body scan is a standard procedure in patients with thyroid cancer prior to the application of therapeutic dose of 131I. Unfortunately, administration of radioisotope in diagnostic dose may decrease further radioiodine uptake – the phenomenon called ‘thyroid stunning’. We estimated radiation absorbed dose-dependent changes in genetic material, in particular in sodium iodide symporter (NIS) gene promoter, and NIS protein lev...

ea0035p1116 | Thyroid Cancer | ECE2014

Thyroglobulin measurements in fine-needle aspiration cytology of lymph nodes in patients after thyroidectomy because of differentiated thyroid cancer

Musial Emilia , Galczynski Jacek , Bakula-Zalewska Elwira , Dedecjus Marek

Introduction: Approximately 5–20% patients treated for differentiated thyroid carcinoma (DTC) develop metastases to the neck lymph nodes. Ultrasound-guided fine-needle aspiration biopsy (FNAB) is a routinely used method in the examination of suspicious lymph nodes. The measurement of thyroglobulin (Tg) levels in needle washout fluids (FNAB-Tg) has been reported to increase the diagnostic accuracy of FNAB.Description of methods/designs: A total of 10...

ea0022p237 | Clinical case reports and clinical practice | ECE2010

Estimation of parathyroid hormone level in patients with primary hyperparathyroidism (PHPT) and negative SPECT scans in the material obtained during fine needle aspiration biopsy (FNAB) of the focal neck lesions

Adamczewski Zbigniew , Dedecjus Marek , Brzezinski Jan , Lewinski Andrzej

Objective: The presence of a single parathyroid adenoma is a cause of primary hyperparathyroidism in most cases. Minimally invasive parathyreoidectomy is a treatment of choice in PHPT patients and precise localization of the changed parathyroids is crucial for successful removal.The aim of the study was to assess usefulness of parathormone level estimation in the material obtained during FNAB of the focal neck lesions in order to differentiate structures...

ea0020p134 | Thyroid | ECE2009

Influence of thyrometabolic state on distribution of subpopulations and fenotypes of dendritic cells in peripheral blood of the patients with chronic thyroiditis and patients monitored because of differentiated thyroid cancer

Dedecjus Marek , Stasiolek Mariusz , Brzezinski Jan , Selmaj Krzysztof , Lewinski Andrzej

Considering, the pivotal role of DC in formation and development of autoimmunological processes, the investigation of influence of of thyrometabolic status on maturation and function of subtypes of human peripheral blood DC, seems to be reasonable and of particular interest. THE AIM of the present study was a complex analysis of the dendritic cell subsets and fenotypes in patients with chronic thyroiditis (ChT) as well as the patients monitored for differentiated thyroid cance...

ea0056ep25 | Adrenal and Neuroendocrine Tumours | ECE2018

Chemodectoma of carotid glomus coexisting with severe hypercalcemia masking parathyroid gland adenoma – diagnostic difficulties

Zylka Agnieszka , Dlugosinska Joanna , Bakula-Zalewska Elwira , Dedecjus Marek

Introduction: Chemodectomas of carotid glomus secret mainly catecholamines and/or ACTH. These tumours are very rare cause of ectopic secretion of parathormone (PTH), althought this possibility should be taken into consideration. Therefore, diagnosis of primary hyperparathyroidism (PHPT) as a cause of hypercalcemia in patients with chemodectoma tumours is problematic and may lead to inappropriate diagnosis and treatment. Presented patient is a 64-years old female with non-opera...

ea0035p1122 | Thyroid Cancer | ECE2014

Rising serum thyroglobulin in the follow-up of patients with differentiated thyroid carcinoma: the role of FDG PET–CT

Godlewska Paulina , Bruszewska Elzbieta , Lapinska Grazyna , Fijolek-Warszewska Agnieszka , Dedecjus Marek

Rising thyroglobulin (Tg) serum concentration in patients after total thyroidectomy due to differentiated thyroid cancer (DTC) with no pathological radioiodine uptake on posttherapeutic whole-body scan (WBS) constitutes a challenge for physicians dealing with DTC management.The FDG PET–CT is regarded as a gold diagnostic standard in such cases.Our aim was to find factors which may help predicting positive PET–CT result, a...

ea0022p861 | Thyroid | ECE2010

Elastography based on tissue Doppler in the diagnosis of thyroid nodules: a pilot study

Adamczewski Zbigniew , Krawczyk-Rusiecka Kinga , Dedecjus Marek , Brzezinski Jan , Lewinski Andrzej

Objective: Aiming at the highest specifity in differentiating benign from malignant thyroid nodules effects in new diagnostics developments. Recent technologies such as elastography enable determination of tissue stiffness difference between focal lesions and surrounding thyroid tissue – reference tissue. This method is based on quantifying the stiffness of the lesion – the malignant changes show decreased elasticity when compared to adjacent tissue. Tissue Doppler u...