Searchable abstracts of presentations at key conferences in endocrinology

ea0035s17.1 | Cushings syndrome | ECE2014

Mortality: still increased despite cure in Cushing’s disease?

Dekkers Olaf

There is considerable evidence that mortality is increased in patients with Cushing’s syndrome of pituitary origin. This is thought to be caused by long-term exposure to supraphysiological cortisol levels inducing harmful effects, such as hypercoagulability, insulin resistance, hypertension, bone loss, and immunosuppression. It is assumed that some cortisol-related effects persist after treatment and the important question is whether this translates in an increased mortal...

ea0016s24.1 | State of the art in the therapy of pituitary disease | ECE2008

Nonfunctioning pituitary macroadenomas: treatment and follow-up

Dekkers Olaf M

Nonfunctioning pituitary macroadenomas are benign tumors, characterized by the clinical and biochemical absence of hormonal overproduction. Clinical symptoms are mainly caused by mass effects of the tumor. The main symptoms are pituitary insufficiencies, visual field defects, decreased visual acuity and headache. For nonfunctioning adenomas with a diameter of less than one cm no treatment is necessary. In patients with a nonfunctioning macroadenoma without visual field defects...

ea0037ep70 | Adrenal cortex | ECE2015

Prevalence of hypercortisolism in type 2 diabetes patients: a meta-analysis

Steffensen Charlotte , Pereira Alberto , Dekkers Olaf M , Jorgensen Jens Otto

Background: Type 2 diabetes (T2D) and hypercortisolism associated with Cushing’s syndrome (CS) share clinical characteristics such as hypertension, dyslipidaemia, hyperglycaemia, and obesity. Several studies have recorded a relatively high prevalence of hypercortisolism in T2D, which may have therapeutic implications. The aim of this systematic review and meta-analysis was to assess the prevalence of hypercortisolism in T2D patients.Methods: Origina...

ea0063p704 | Pituitary and Neuroendocrinology 2 | ECE2019

Sex differences in presentation but not in outcome for ACTH-dependent Cushing’s syndrome

Broersen Leonie , Haalen Femke van , Kienitz Tina , Biermasz Nienke , Strasburger Christian , Dekkers Olaf , Pereira Alberto

Background: Sex differences in clinical picture of ACTH-dependent Cushing’s syndrome are controversial, except for the known higher prevalence in females. We compared a broad range of potential differences to enable a more accurate understanding of the clinical picture of sex-specific ACTH-dependent Cushing’s syndrome.Design: Cohort study.Methods: We included consecutive patients with ACTH-dependent Cushing’s syndrom...

ea0063p705 | Pituitary and Neuroendocrinology 2 | ECE2019

Adrenal crisis in treated patients with Cushing’s syndrome

Broersen Leonie , Haalen Femke van , Kienitz Tina , Dekkers Olaf , Strasburger Christian , Pereira Alberto , Biermasz Nienke

Background: Adrenal crisis, the most feared complication of adrenal insufficiency, is a potentially life-threatening situation of acute glucocorticoid deficiency. After successful surgery, many patients with Cushing’s syndrome develop (transient) adrenal insufficiency. The incidence of adrenal crisis in patients treated for hypercortisolism is unknown.Methods: Cohort study including consecutive patients with Cushing’s syndrome with adrenal insu...

ea0049oc12.2 | Pituitary Clinical | ECE2017

Use of temozolomide in a large cohort of patients with aggressive pituitary tumours and pituitary carcinomas: Results from a European Society of Endocrinology (ESE) survey

McCormack Ann , Dekkers Olaf M , Petersenn Stephan , Popovic Vera , Trouillas Jacqueline , Raverot Gerald , Burman Pia

Objective: To collect clinical and treatment outcome data in a large patient cohort, and specifically to report experience with temozolomide (TMZ).Design: Cohort study based on an electronic survey open for participation to ESE members Dec 2015-Nov 2016.Results: Reports on 167 patients, 40 pituitary carcinomas, and 127 aggressive pituitary tumours were obtained. Median age at diagnosis was 43 (range 4–79) years. 59% of tumours...

ea0032oc2.4 | Bone & Calcium | ECE2013

Natural course of changes in bone mineral density after orthotopic liver transplantation: up to 5 years follow-up in a single centre

Krol Charlotte , Dekkers Olaf , Meiland Desi , van Hoek Bart , Hamdy Neveen

Introduction: Low energy trauma fractures are prevalent in end-stage liver disease and after orthotopic liver transplantation (OLT). However, data on bone mineral density (BMD) are scarce in these patients. In this study, we evaluated the natural course of changes in BMD after successful OLT.Study design: All recipients of a successful OLT between 2000 and 2011 from the Leiden University Medical Centre, in whom BMD data were available, were included. Pat...

ea0073aep463 | Pituitary and Neuroendocrinology | ECE2021

Epidemiology of acromegaly in south-eastern Norway

Falch Camilla Maria , Olarescu Cristina , Bollerslev Jens , Dekkers Olaf M. , Heck Ansgar

ObjectiveIn order to improve therapeutic outcomes for patients with acromegaly, new treatment algorithms have been developed over the last decades. Valid epidemiological data of acromegaly in Norway is lacking. The overall aim of this study was to investigate incidence, prevalence and mortality of acromegaly in South-Eastern Norway, and to investigate effects of new treatment algorithms.Design and methodPatie...

ea0049gp17 | Adrenal 2 | ECE2017

Hypercortisolism is prevalent in newly diagnosed type 2 diabetes: a prospective study of 384 consecutive patients

Steffensen Charlotte , Dekkers Olaf M , Lyhne Johanne , Poulsen Per L , Rungby Jorgen , Sorensen Henrik T , Jorgensen Jens Otto L

Background: Cross-sectional studies in small and selected populations indicate a relatively high prevalence of incipient and/or subclinical Cushing’s syndrome (CS) in patients with type 2 diabetes (T2D), which could have therapeutic implications.Aim: To estimate the prevalence of CS in a large, unselected cohort of recently diagnosed T2D patients.Methods: A total of 384 consecutive out – patients with T2D diagnosed after ...