Endocrine Abstracts

Background: Kisspeptin is a critical activator of hypothalamic GnRH neurons and is essential for reproductive health. Emerging data reveals that kisspeptin-based therapeutics have substantial potential to treat reproductive, psychosexual and bone disorders. However, current delivery is limited to the subcutaneous or intravenous routes, presenting barriers to development. Alternative routes of administration would overcome this and capitalise on the benefits of kisspeptin-based...

Background: Kisspeptin is a potent regulator of GnRH neurons with potential to treat reproductive and psychosexual disorders. However, administration is limited to the subcutaneous or intravenous routes. These invasive routes limit clinical development. Herein, we comprehensively examine the translational potential of intranasal kisspeptin administration for the first-time using rodent, human and pharmaceutical studies.Methods:</...