Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep28 | Adrenal cortex (to include Cushing's) | ECE2016

Adenoma size could be an important predictor of Subclinical Cushing’s Syndrome

Yener Serkan , Baris Mustafa , Demirpence Mustafa , Ozisik Secil , Cavdar Umit , Demir Omer , Secil Mustafa , Comlekci Abdurrahman

Subclinical Cushing’s syndrome (SCs) is used to refer to an adrenal incidentaloma with subtle autonomous cortisol secretion and without typical signs and symptoms of hypercortisolism. Diagnostic criteria are uncertain and arbitrary. In this study we aimed to investigate the power of adenoma size as an independent predictor of SCs.Dokuz Eylul University Adrenal Tumours Study Group database includes 596 patients by January 2016. Briefly, there are 332...

ea0037ep62 | Adrenal cortex | ECE2015

Prospective evaluation of cardiovascular risk in subclinical Cushing's syndrome

Yener Serkan , Cekdemir Yasin , Baris Mustafa , Demirpence Mustafa , Demir Tevfik , Secil Mustafa

Introduction: Natural history of adrenal incidentalomas has not been totally understood. Current data from subjects with adrenal incidentalomas demonstrated an increased rate of metabolic disturbances and cardiovascular risk. It has been shown that subjects with subclinical cortisol excess were more susceptible to diabetes, hypertension, and obesity. However, there is no data regarding prospective cardiovascular risk evaluation in subjects with subclinical Cushing’s syndr...

ea0041ep2 | Adrenal cortex (to include Cushing's) | ECE2016

Effect of heterophilic antibody interference in ACTH immunoassay to Subclinical Cushing’s Syndrome screening: A pilot study

Yener Serkan , Ozisik Seciil , Cavdar Umit , Demirpence Mustafa , Comlekci Abdurrahman

Heterophilic antibodies are well-known interferent factors affecting most immunoassays. However, they have been poorly evaluated in routine clinical practice. Definition of Subclinical Cushing’s Syndrome (SCs) has been arbitrary and prevalence has shown significant variations related with the diversity of the diagnostic tests. In most of the guidelines a low or suppressed corticothropin (ACTH) level has been suggested as an important predictor of SCs. Here, we sought to i...

ea0037ep217 | Reproduction, endocrine disruptors and signalling | ECE2015

Subclinical hypothyroidism in patients with polycystic ovary syndrome

Yasar Hamiyet Yilmaz , Topaloglu Omercan , Demirpence Mustafa , Ceyhan Banu Ozturk

Objective: Polycystic ovary syndrome (PCOS) is a common endocrine metabolic disorder that affects 5–10% of women of reproductive age. In various studies, it was found to be associated with subclinical hypothyroidism. Serum TSH levels were also reported to be increased in obese individuals. In order to define the impact of obesity on the subclinical hypothyroidism observed in patients with PCOS, we aimed to investigate subclinical hypothyroidism both in lean and overweight...

ea0037gp.19.01 | Pituitary–Acromegaly | ECE2015

Coagulation parameters and platelet function analysis in patients with acromegaly

Yasar Hamiyet Yilmaz , Demirpence Mustafa , Colak Ayfer , Ceyhan Banu Ozturk , Temel Yusuf , Simsek Nese , Karademirci Ismail , Bozkurt Umit

Objective: Acromegaly is associated with increased cardiovascular morbidity and mortality. But the data about the evaluation of coagulation and fibrinolysis in acromegalic patients is very limited and to our knowledge, platelet function analysis has never been investigated. So we aimed to investigate the levels of protein C, protein S, fibrinogen, antithrombin 3, and platelet function analysis in patients with acromegaly.Methods: Thirty-nine patients wit...

ea0056p812 | Pituitary - Clinical | ECE2018

Is elevated urotensin II level a predictor for increased cardiovascular risk in subjects with acromegaly?

Demirpence Mustafa , Guler Asli , Yilmaz Hamiyet , Sayin Ahmet , Pekcevik Yeliz , Turkon Hakan , Colak Ayfer , Ari Elif Merve , Aslanipour Behnaz , Kocabas Gokcen Unal , Calan Mehmet

Purpose: Acromegaly, an uncommon disease, is existed in the result of over production of growth hormone (GH). It is associated with increased cardiovascular risk factors and metabolic abnormalities. Urotensin II (UII), a secreted vasoactive peptide hormone, plays an essential role in the regulation of vascular tone, glucose metabolism and atherosclerosis. UII belonging to somatostatin superfamily activates somatostatin receptors as well. The aim of this study was to ascertain ...