Searchable abstracts of presentations at key conferences in endocrinology

ea0039ep64 | Diabetes | BSPED2015

Audit of DKA admission rates in children and young adults 2010–2015

Chee Carolyn , Chhugani Karuna , Denvir Louise

Introduction: The National Paediatric Diabetes Audit (NPDA) in 2012 reported a twofold increase in the incidence of diabetes ketoacidosis (DKA) admissions from 2005/6 to 2010/11 in children and young people with type 1 diabetes mellitus (T1DM). The paediatric diabetes best practice tariff (BPT) was introduced in 2012 to incentivise provision of high quality care to those under the age of 19.Aims: We examined DKA admission rates in children and young adul...

ea0051p062 | Diabetes | BSPED2017

How effective is stabilisation at reducing HbA1c levels in children with T1DM on the high HbA1c pathway in Nottingham?

Moreton William , Verhoeven Vreni , Denvir Louise , Randell Tabitha , Sachdev Pooja

Background: Recent NPDA 15/16 data shows that nationally 17.9% of children and young people (CYP) with type 1 diabetes mellitus (T1DM) have a HbA1c level >80 mol/mol (7.9% at Nottingham Children’s Hospital (NCH)), putting them at increased risk of diabetic ketoacidosis and long-term sequelae. To support patients on the high HbA1c pathway (>80 mmol/mol) at NCH, a 5-day inpatient stay for stabilisation is offered. The process involves daily re-education from paediat...

ea0036P17 | (1) | BSPED2014

Neonatal seizure: a rare presentation of maternal hyperparathyroidism

Dunn Lucy , Ashmore Laura , Randell Tabitha , Denvir Louise , Sachdev Pooja

Introduction: Hypocalcaemia is a recognised cause of neonatal seizures most often related to vitamin D deficiency in the mothers of exclusively breast fed infants. There have also been case reports of an underlying diagnosis of hyperparathyroidism in a reportedly well mother becoming apparent after the infant presents with hypocalcaemic seizures. Maternal hypercalcaemia suppresses parathyroid activity in the foetus, which causes transient neonatal hypocalcaemia.<p class="a...

ea0036P27 | (1) | BSPED2014

Children with type 1 diabetes and coeliac disease at Nottingham Children's Hospital: a service review and evaluation

Ashcroft Jennifer , Randell Tabitha , Denvir Louise , Sachdev Pooja

Introduction: The prevalence of coeliac disease (CD) in type 1 diabetes (T1DM) is 4.4–11.1 vs 0.5% in the general population. The compliance to gluten free diet (GFD) in symptomatic patients vs those diagnosed on screening is significantly higher as expected. The impact of untreated CD on patients with T1DM ranges from malabsorption and frequent unexplained hypoglycaemia to no symptoms.Aims: i) To describe the demographics of our children with CD.</...

ea0036P50 | (1) | BSPED2014

Sex chromosome mosaicism in males: our experience

Santhanam Priyha , Sachdev Pooja , Denvir Louise , Randell Tabitha

Introduction: 45XO/46XY karyotype has varied phenotypic spectrum ranging from short stature, ambiguous genitalia (60%), clinical signs of Turner’s syndrome in both males and females and normal male phenotype. We report six phenotypically male cases with a varied clinical presentation.Case 1 and 2: Short stature: Two pre-pubertal, phenotypical males, were referred with concerns regarding short stature (height <0.4th centile, height velocity &#150...

ea0058p057 | Diabetes | BSPED2018

Type 1 diabetes cohort with HbA1c ≤ 48 mmols/mol April 2017 – March 2018 – what have we learnt?

Saddington Caroline , Sachdev Pooja , Randell Tabitha , Denvir Louise

Background: 71/270 (26%) of our patients with T1DM, diagnosed for more than 1 year, had an ideal HbA1c of less than or equal to 48 mmol/mol. Are there factors within this group that may be transferred into groups with higher HbA1cs to improve control?Methods: Clinical records were reviewed for the whole year and download data from a randomly selected 2 week period was reviewed. Age, gender, time from diagnosis, ethnicity, postcode, other medical conditio...

ea0033p35 | (1) | BSPED2013

Tired, tachycardic, toxaemic, teenagers: fluids in severe DKA

Frerichs Carley , Davies Patrick , Alurkar Shri , Randell Tabitha , Denvir Louise

DKA guidelines aim to reduce risk of cerebral oedema. We present the outcomes of three young females with severe DKA with reduced conscious level at diagnosis that required deviation from these guidelines.A. 12-year-old, pH 6.88 with DKA and sepsis. Received 20 ml/kg initial fluid bolus. CT head scan was normal. Hypotension required further fluid boluses, inotropes and an increase in fluids to 65% above the rate on DKA protocol. Although slow to wake aft...

ea0045p13 | Diabetes | BSPED2016

Practical Elements for Successful Recruitment of Patients and Families with Newly Diagnosed Type 1 Diabetes (T1DM) into a Research Study

Saddington Caroline , Mohamed Zainaba , Sachdev Pooja , Denvir Louise , Randell Tabitha

Background: The paediatric diabetes team at our Children’s Hospital were part of a national clinical trial considering whether long term outcomes are better for patients on MDI (multiple daily injection therapy) or insulin pump therapy from diagnosis. Patients and their families had to be approached, consented and treatment for the trial commenced within two weeks of diagnosis. Many centres struggled to recruit, but this was not the case with our centre.<p class="abst...

ea0045p16 | Diabetes | BSPED2016

An Audit of the Paediatric Diabetes Out Of Hours Advice Service using the Best Practice Tariff Criteria

Starr Emma , Quintela Ella , Denvir Louise , Sachdev Pooja

Background/Introduction: The Best Practice Tariff was introduced in 2012 in England and Wales to provide adequate funding and ensure quality care for all children with Diabetes. The tariff criteria states that units must provide “24 hour access to advice and support” including “24 hour expert advice to other healthcare professionals”. The aims of this audit were to: evaluate the Nottingham Children’s Hospital out of hours paediatric diabetes service, d...

ea0045p21 | Diabetes | BSPED2016

Efficacy and uptake of an education clinic integrated into an MDT clinic for children with type 1 diabetes

Quintela Ella , Drew Josephine , Denvir Louise , Randell Tabitha , Sachdev Pooja

Introduction: The Best Practice Tariff states that units must provide a structured education programme which should be ‘tailored to the child’s needs, both at the time of initial diagnosis and ongoing updates’. Traditionally, there has been poor uptake of our education sessions with attendance rates of 20% (range 0–30). Therefore, an integrated education clinic was introduced which combined education within a multidisciplinary (MDT) clinic session for ongoi...