Searchable abstracts of presentations at key conferences in endocrinology

ea0032p336 | Developmental Endocrinology | ECE2013

Effects of pharmacological and genetic manipulation of glucocorticoids during early development of the zebrafish embryo

Wilson Kathryn , Matrone Gianfranco , Tucker Carl , Hadoke Patrick , Kenyon Christopher , Mullins John , Denvir Martin

Background: The effects of glucocorticoids (GC) on the developing zebrafish embryo (Zfe) are poorly characterised. We have assessed the effects of pharmacological and genetic manipulation of cortisol and glucocorticoid receptors (GR) on global development and stress response during the first 120 hpf.Methods: Cortisol production was modulated by inhibiting the enzyme 11b hydroxylase using morpholino gene knockdown (MO) or incubation in the drug metyrapone...

ea0034p361 | Steroids | SFEBES2014

Endogenous androgen-mediated modulation of neointima formation is independent of vascular androgen receptor

Wu Junxi , Hadoke Patrick , Mair Iris , Lim Win Gel , Millar Eileen , Milne Laura , Denvir Martin , Smith Lee

Aims: Low circulating testosterone levels are associated with increased cardiovascular risk and there is evidence that androgens inhibit arterial lesion formation. This investigation addressed the hypothesis that androgens directly inhibit neointimal lesion formation by stimulation of vascular androgen receptor.Methods and results: Mice were generated with selective deletion of androgen receptor from vascular (endothelial or smooth muscle) cells. Castrat...