Searchable abstracts of presentations at key conferences in endocrinology

ea0014p272 | (1) | ECE2007

CRF and the Urocortins activate NFAT and induce catecholamine production in PC12 cells

Dermitzaki Erini , Tsatsanis Christos , Androulidaki Ariadne , Venihaki Maria , Gravanis Achille , Margioris Andrew

We have previously shown that Corticotropin – releasing factor (CRF) and Urocortins (UCNs) induce the production of catecholamines from normal human and rat adrenal chromaffin and PC12 pheochomocytoma cells via induction of tyrosine hydroxylase, the rate limiting enzyme of catecholamine biosynthesis. We have also shown that CRF induces calcium ion entrance into the cytoplasm from both extracellular sources (influx) and from intracellular stores (mobilization) in PC12 cell...