Searchable abstracts of presentations at key conferences in endocrinology

ea0014p136 | (1) | ECE2007

Leptin and adiponectin interact in regulating prostate cancer cell growth

Mistry Tina , Digby Janet , Desai Ken , Randeva Harpal

Introduction: Leptin and adiponectin have opposing properties and are implicated as molecular mediators between obesity and (aggressive) prostate cancer. Adiponectin, circulates inversely proportional to visceral fat accumulation, and has demonstrated anti-proliferative effects in prostate cancer cells; circulating leptin levels increase with visceral fat accumulation and has shown mitogenic effects. We propose that adiponectin and leptin interact in prostate cancer cell growt...

ea0014p137 | (1) | ECE2007

A novel role for Visfatin/Pre-B cell colony-enhancing factor 1 (PBEF)/Nicotinamide phosphoribosyltransferase (NMPRTase) in prostate carcinogenesis

Mistry Tina , Digby Janet , Cross Joe , Desai Ken , Randeva Harpal

Introduction: Visfatin/PBEF is a novel adipokine circulating inversely proportional to visceral fat mass and exerts insulin-mimetic effects; it is expressed in normal, inflamed and tumour tissues. Visfatin/PBEF has also been identified as NMPRTase, a key intracellular enzyme involved in NAD+ metabolism, replenishing NAD+ during cellular respiration. Inhibition of NMPRTase by the anti-cancer agent FK866 has been shown to induce apoptosis in tumours. Prosta...