Endocrine Abstracts

The orphan nuclear receptor, steroidogenic factor-1 (SF-1) regulates gonadotroph development and gene expression. In the absence of an identified ligand, SF-1 has been shown to be constitutively active and recent studies reveal that post-translational modification may regulate its transcriptional activity. The Ser 203 residue, proximally located to helix 1 of the ligand binding domain (LBD) of SF-1, resides in a consensus MAPK phosphorylation site, and is required for full tra...

The Nuclear Receptor Subfamily 5A member, Steroidogenic Factor 1 (SF-1, Ad4BP, NR5A1), is critical for steroidogenesis, stress responses, sexual differentiation and body weight regulation in mice. Patients with rare mutations in SF-1 have confirmed its role in male sexual differentiation and adrenal response to physiological stress in humans. In contrast, Liver Receptor Homologue 1 (LRH-1, FTF, CPF, NR5A2) is involved in endoderm development, bile acid and lipid metabolism and...