Searchable abstracts of presentations at key conferences in endocrinology

ea0081p661 | Pituitary and Neuroendocrinology | ECE2022

Metyrapone vs osilodrostat in the short-term therapy of endogenous Cushing’s syndrome: results from a retrospective single center analysis

Detomas Mario , Altieri Barbara , Deutschbein Timo , Fassnacht Martin , Dischinger Ulrich

Background: Although surgery is considered the first-line treatment for patients with endogenous Cushing’s syndrome (CS), medical therapy is often required to control severe hypercortisolism. Metyrapone and osilodrostat are inhibitors of 11β-hydroxylase that have not been directly compared yet.Methods: Retrospective analysis of patients with adrenocorticotropin (ACTH)-dependent and ACTH-independent CS treated with metyrapone or osilodrostat (as...

ea0090ep41 | Adrenal and Cardiovascular Endocrinology | ECE2023

The role of CRH test in predicting the efficacy of unilateral adrenalectomy in Bilateral Macronodular Adrenal Hyperplasia

Tizianel Irene , Detomas Mario , Deutschbein Timo , Carla Scaroni , Ceccato Filippo

Background and Aim: Bilateral Macronodular Adrenal Hyperplasia (BMAH) is a rare form of adrenal Cushing’s syndrome (CS). The treatment of choice in patients with BMAH and overt CS is bilateral adrenalectomy (B-Adx), which however implies lifelong glucocorticoid and mineralocorticoid replacement therapy. Unilateral adrenalectomy (U-Adx) has been proposed as an alternative to B-Adx, especially in case of clearly asymmetric adrenal size. Our aim was to determine predictive f...

ea0020p31 | Adrenal | ECE2009

Confounding variables for plasma metanephrines and normetanephrines may influence the diagnosis of pheochromocytomas

Deutschbein Timo , Jager Andrea , Mann Klaus , Petersenn Stephan

Introduction: Measurements of plasma metanephrines (META) and normetanephrines (NOR) have been advocated as first-line tests for the diagnosis of pheochromocytoma. This study assessed the impact of several potential confounders, which may influence the correct diagnosis.Methods: Eight healthy males (age 26.8±1.7; BMI 23.1±0.8) were tested on 6 separate days. Tests were performed in supine rest with blood sampling via i.v. canullas at 0900 h fol...

ea0016p595 | Paediatric endocrinology | ECE2008

Day profiles of salivary 17-hydroxyprogesterone for the control of glucocorticoid therapy in adolescents with congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Deutschbein Timo , Unger Nicole , Hauffa Berthold , Mann Klaus , Petersenn Stephan

Introduction: Optimizing glucocorticoid (GC) therapy in patients with congenital adrenal hyperplasia (CAH) remains a challenge. While overdosing may result in Cushing’s syndrome, underdosing is associated with female virilization and adrenal insufficiency. This study evaluated day-profiling of salivary 17-hydroxyprogesterone (17OHP) for the biochemical control of adolescents with CAH due to 21-hydroxylase deficiency.Methods: Twelve patients (4 males...

ea0041gp160 | Pituitary - Clinical (1) | ECE2016

Anthropometric factors have significant influence on the outcome of the GHRH-arginine test – establishment of normative data

Deutschbein Timo , Bidlingmaier Martin , Schopohl Jochen , Strasburger Christian J , Petersenn Stephan

Background: Adult GH deficiency (GHD) is diagnosed by provocative testing of GH secretion. To improve diagnostic accuracy of GHRH plus arginine (GARG) testing, we evaluated the influence of age, BMI, and sex. Furthermore, we aimed to established normative data for an automatic immunoassay specifically measuring 22kD human GH.Methods: Eighty-seven patients with hypothalamic-pituitary disease and 200 healthy controls were enrolled. Controls were prospectiv...

ea0022p55 | Adrenal | ECE2010

Influence of various clinical variables and storage conditions on urinary cortisol levels: gas chromatography–mass spectrometry (GC–MS) versus immunoassay

Deutschbein Timo , Broecker-Preuss Martina , Hartmann Michaela , Wudy Stefan , Althoff Ricarda , Mann Klaus , Petersenn Stephan

Introduction: Measurement of urinary cortisol is often used to assess disease activity in patients with suspected or proven hypercortisolism. However, specific reference ranges are lacking for some of the newer assays. This study analyzed upper limits of normal (ULN, mean+2S.D.) for two analytical procedures (GC–MS, ECLIA) in relation to various independent variables. Besides, the influence of different storage conditions was investigated (by ECLIA).<p ...

ea0022p396 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Outcome of two chemotherapies in the treatment of progressive, undifferentiated neuroendocrine carcinomas: a single-center experience

Deutschbein Timo , Unger Nicole , Yuece Ali , Lahner Harald , Mann Klaus , Petersenn Stephan

Introduction: Treatment of poorly differentiated neuroendocrine tumors (NET) usually includes chemotherapeutic intervention. However, both the rarity and the heterogeneity of the disease have led to relatively few clinical trials. This study evaluated the outcome of two chemotherapy regimens in patients suffering from undifferentiated and histologically confirmed NET.Methods: Eighteen patients (11 males; age 56.7±2.5) with proven progressive disease...

ea0081p153 | Pituitary and Neuroendocrinology | ECE2022

Subtype-specific pattern of white blood cell differential in endogenous Cushing’s syndrome

Detomas Mario , Altieri Barbara , Chifu Irina , Remde Hanna , Landwehr Laura-Sophie , Sbiera Silviu , Kroiss Matthias , Fassnacht Martin , Deutschbein Timo

Objective: Glucocorticoid excess impairs immune function, thereby predisposing patients with endogenous Cushing’s syndrome (CS) to infections. However, it is still not clear whether there is a CS-subtype specific pattern in white blood cell (WBC) and WBC differential (WBCD) count.Methods: Retrospective monocentric cohort study in patients with either overt endogenous CS or adrenal adenomas with autonomous cortisol secretion (ACS), with WBC and WBCD ...

ea0090p681 | Pituitary and Neuroendocrinology | ECE2023

Erythropoiesis in endogenous Cushing syndrome: sex-related and subtype-specific differences

Detomas Mario , Deutschbein Timo , Tamburello Mariangela , Chifu Irina , Kimpel Otilia , Sbiera Silviu , Kroisz Matthias , Fassnacht Martin , Altieri Barbara

Context: Endogenous Cushing syndrome (CS) is associated with hematological abnormalities. Nevertheless, conflicting data have been reported on erythropoiesis. Some studies reported an association between CS and anemia in men, whereas others described erythrocytosis in affected patients. Furthermore, it is unclear whether there are CS subtype-specific changes in red blood cells (RBC) parameters.Objective: To investigate sex and subtype-specific changes in...

ea0041ep609 | Endocrine tumours and neoplasia | ECE2016

Craniopharyngioma registry for adult patients, an initiative of the pituitary workgroup of the DGE

Mende Klaus Christian , Kopczak Anna , Deutschbein Timo , Droste Michael , Honegger Jurgen , Stalla Gunther , Muller Herrmann , Petersenn Stephan , Flitsch Jorg

Introduction and Objective: Adult craniopharyngioma as a rare neoplasm of the central nervous system is still very poorly understood. The clinical implications for affected patients are numerous, ranging from endocrine dysfunction to visual loss and neurological impairment. Although the progress of this tumor entity is slow by nature, affected patients often suffer from multiple symptoms even after successful treatment with a strong impact on their individual quality of life. ...