Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep872 | Pituitary - Clinical | ECE2016

Endocrinologic outcomes of gamma knife radiosurgery for acromegaly: from an endocrine clinic

Uygur Meliha Melin , Deyneli Oguzhan , Yavuz Dilek Gogas

Although surgical resection is the usual initial treatment for patients with acromegaly, it does not always lead to a remission. Gamma knife radiosurgery (GKRS) is an important additional strategy for unresected clinically active pituitary adenomas.Objective: We evaluated retrospectively pituitary hormone status as well as the efficacy of GKRS for patients with acromegaly referred to our tertiary endocrinology clinic. Prognostic factors related to outcom...

ea0041ep915 | Pituitary - Clinical | ECE2016

Prolactin measurements improve the diagnostic accuracy of inferior petrosal sinus sampling

Uygur Meliha Melin , Yasar Mehmet , Deyneli Oguzhan , Yavuz Dilek Gogas

Introduction: Inferior petrosal sinus sampling for ACTH is the current gold standard test for the differentiation of pituitary Cushing disease from the ectopic ACTH syndrome. Early studies with İPSS reported a diagnostic sensitive and specificity approaching 100%, additional experience has shown a false negative rate of 1-10%. This has been due to either technical problem with unsuccessful petrosal sinus catheterization or anomalous venous drainage of the pituitary. The ...

ea0049ep47 | Adrenal cortex (to include Cushing's) | ECE2017

Effect of adrenal mass lateralization on diagnostic tests in patients with Cushing

Tarcin Ozlem Ustay , Pehlevan Emre , Imre Eren , Uygur Melin , Deyneli Oguzhan , Yavuz Dilek Gogas

The frequency of adrenal masses is increasing in parallel with the progress of the technology. Most of these masses, which are detected by chance, are not functional, and only a part of them are exposed to an excess of hormone. The most common dysfunction in masses with hormonal activity is hypercortisolism. However, the diagnosis of Cushing’s disease is based on more than one test. In this study, we intended to compare the values of screening tests to determine whether t...

ea0049ep851 | Clinical case reports - Pituitary/Adrenal | ECE2017

Pachydermaperiostosis: a rare syndrome presented with acromegaloid changes

Uygur Meliha Melin , Arikan Izzet Hakki , Deyneli Oguzhan , Yavuz Dilek Gogas

Introduction: Pachydermoperiostosis (PDP) is a rare hereditary syndrome with familial and idiopathic forms that is characterized by subperiosteal new bone formation with pain, polyarthritis, cutis vertices grata, seborrhea, hyperhidrosis and digital clubbing. Periostosis and cutaneous thickening along with the absence of any signs of cardiovascular, pulmonary, hepatic, intestinal and mediastinal diseases causing secondary hypertrophic osteoarthropathy suggest PDP. The incidenc...

ea0032p848 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Advanced glycation end product associated skin autofluorescence and serum corboxymethyl lysine levels in acromegaly

Yavuz Dilek Gogas , Yalin Serap , Yazici Dilek , Yasar Mehmet , Deyneli Oguzhan

Aim: Nonenzymatic advanced glycation and oxidation end-products, advanced glycation end-products (AGEs), impart a potent impact on vessels in diabetic state and in euglycaemic conditions with increased oxidative stress.The aim of this study is to measure AGEs and its relationship with carotid intimae media thickness (CIMT) in acromegaly patients.Method: A case–control study was performed in 225 acromegalic patients (F/M: 116/1...

ea0020p195 | Endocrine tumours and neoplasia | ECE2009

Microalbuminuria and insulin resistance in nondiabetic acromegalic patients

Yalin Ayse Serap , Sancak Seda , Deyneli Oguzhan , Gunes Mutlu , Yavuz Dilek Gogas , Akalin Nefise Sema

Growth hormon (GH) counteracts the effects of insulin on glucose metabolism and GH excess may lead to insulin resistance (IR). Impaired glucose tolerance (IGT) and diabetes mellitus (DM) are frequently associated with acromegaly. Microalbuminuria (MAU) is a well established cardiovascular (CV) risk factor and a predictor of CV mortality in both diabetic and nondiabetic subjects.The aim of this preliminary study was to investigate the MAU levels as a mark...

ea0014p406 | (1) | ECE2007

Carotid intima media thickness and bone turnover in type 2 diabetic patients

Sancak Seda , Yavuz Dilek , Toprak Ahmet , Deyneli Oguzhan , Tarcin Ozlem , Yazici Dilek , Aydin Hasan , Akalin Sema

Recent studies indicate that atherosclerotic process is associated with bone metabolism. The aim of this study was to evaluate carotid intima media thickness (CIMT) and its association with bone mineral density and bone turnover markers as well as inflammation markers in type 2 diabetic male patients.Material-method: 184 type 2 diabetic males (56±8 y) and 85 non-diabetic control subjects (52±7 y) were recruited. Bone mineral density was measure...

ea0014p415 | (1) | ECE2007

Evaluation of diastolic function and its relationship with carotis intima media thickness and endothelial function in asymtomatic hyperparathyroid patients

Yazici Dilek , Tarcin Ozlem , Ozben Beste , Toprak Ahmet , Deyneli Oguzhan , Sancak Seda , Yavuz Dilek , Akalin Sema

Symptomatic hyperparathyroid patients are under risk of increased cardiovascular mortality, associated with left ventricular hypertrophy, diastolic dysfunction and accelerated atherosclerosis. Data on asymptomatic hyperparathyroid patients are conflicting. This study aimed to determine diastolic dysfunction and its association with carotis intima media thickness (CIMT) and flow-mediated vasodilation (FMD) in a group of asymptomatic hyperparathyroid patients.<p class="abste...

ea0032p919 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Transsphenoidal surgery, gamma-knife surgery and diabetes are the factors affecting the quality of life in acromegalic patients

Yalin Ayse Serap , Sancak Seda , Deyneli Oguzhan , Gunes Mutlu , Temizkan Sule , Yavuz Dilek Gogas , Akalin N. Sema

Generously supported by IPSEN)-->Acromegaly is a chronic disease with an important impact on patients, health-related quality of life (HRQoL). Acromegaly quality of life questionnaire (AcroQoL) is a disease-generated QoL questionnaire comprising 22 questions each having five possible responses scored 1–5, the maximum score of 110 reflecting best possible QOL, and quoted as a percentage. The 22 items break down into two categorie...

ea0022p410 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Evaluation of respiratory function in acromegalic patient

Serap Yalin Ayse , Sancak Seda , Temizkan Sule , Gunes Mutlu , Deyneli Oguzhan , Yavuz Dilek , Karakurt Sait , Sema Akalin Nefise

Acromegaly alters elasticity, structure and function of the respiratory system and respiratory disorders constitute 25% of all deaths recorded in acromegalic patients. Respiratory mortality is three fold higher than in normal subjects. However, respiratory dysfunction in acromegaly has seldom been investigated.We aimed to evaluate the extent of pulmonary dysfunction in acromegalic patients with respiratory function tests (RFT). Sixty one acromegalic pati...