Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep820 | Steroid metabolism + action | ECE2017

Reference values for the urinary steroid metabolome: the impact of sex and age on human adult steroidogenesis

Ackermann Daniel , Ponte Belen , Pruijm Menno , d'Uscio Claudia H. , Guessous Idris , Ehret Georg , Paccaud Fred , Pechere-Bertschi Antoinette , Martin Pierre-Yves , Burnier Michel , Dick Bernhard , Vogt Bruno , Bochud Murielle , Dhayat Nasser A.

Background: Urinary steroid metabolomics by GC-MS is an established method in clinic and research to describe steroidogenic disorders, but normative data are scarce.Methods: The 24-hour urinary excretion of 40 steroid metabolites was measured by GC-MS in 1128 adult participants of the Swiss Kidney Project on Genes in Hypertension (SKIPOGH), a multicenter, family-based, cross-sectional study. Sex- and age-specific reference ranges were created in the unit...