Searchable abstracts of presentations at key conferences in endocrinology

ea0081p298 | Calcium and Bone | ECE2022

Evaluation of pth deprivation effects on spatial memory in a rat model of chronic post-surgical Hypoparathyroidism

Saponaro Federica , Ronca Francesca , Dettori Cristina , Frascarelli Sabina , Di Buono Giulia , Giacomelli Silvia , Chiellini Grazia , Scalese Marco , Cetani Filomena , Marcocci Claudio , Zucchi Riccardo

Introduction: Hypoparathyroidism (HypoPT) is a rare endocrine disease which is characterized by hypocalcaemia and undetectable or inappropriately low serum parathyroid hormone (PTH). Post-surgical HypoPT (PS-HypoPT) is the most common cause, caused by accidental parathyroid removal/injury during neck surgery. Conventional therapy with calcium and vitamin D analogues does not restore calcium homeostasis and patients with chronic PS-HypoPT complain with several complications. Fr...