Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp142 | Interdisciplinary Endocrinology 1 | ECE2019

Impact of age and metabolic profile on the definition of 12 circulating steroid reference intervals measured by LC-MS/MS in an Italian healthy adult male cohort

Mezzullo Marco , Di Dalmazi Guido , Fazzini Alessia , Ibarra Gasparini Daniela , Pelusi Carlotta , Pagotto Uberto , Fanelli Flaminia

Background: Steroid profiling by LC-MS/MS is increasingly used in endocrine research, and is being introduced in the clinical practice. Due to the large disagreement with previous immunoassays, and to the enlarged panel of measurable steroids, novel and robust reference intervals (RIs) need to be established. Steroid circulating levels are known to be influenced by several physio-pathological factors, such as age, gender, stress and metabolic status. Therefore, generating unbi...

ea0063gp143 | Interdisciplinary Endocrinology 1 | ECE2019

Impact of age, menstrual phase, menopausal status and metabolic profile on the definition of 12 circulating steroid reference intervals measured by LC-MS/MS in an Italian healthy adult female cohort

Mezzullo Marco , Di Dalmazi Guido , Fazzini Alessia , Ibarra Gasparini Daniela , Gambineri Alessandra , Pagotto Uberto , Fanelli Flaminia

Endocrine clinical practice strongly relies on normative data for the assessment of hormonal imbalance. However, the generation of robust steroids reference intervals (RIs) remains a challenge. As the steroids circulating levels are influenced by many procedural aspects related to blood collection (time, fasting state) and physio-pathological factors, such as age, sex, stress and metabolic status, the need for partitioning RIs is mandatory. Furthermore, unbiased healthy, drug-...

ea0063p502 | Calcium and Bone 2 | ECE2019

Evaluation of bone metabolism in women on aromatase-inhibitors before and after antiresorptive treatment

Vandi Giulia , Zavatta Guido , Repaci Andrea , Di Dalmazi Guido , Altieri Paola , Pagotto Uberto

Introduction: Adjuvant therapy with aromatase-inhibitors (AIs) increases bone loss and fracture risk. Concomitant antiresorptive treatment is currently recommended. The aim of this study was to evaluate the effects of AIs on bone metabolism and mineral density at 12 and 24 months.Methods: Among 400 women on AIs who attended our Endocrinology Unit from 2014 to 2016, we retrospectively evaluated those who initially refused antiresorptive and took cholecalc...

ea0063p515 | Calcium and Bone 2 | ECE2019

Denosumab, alendronate and zoledronate failure to suppress bone resorption markers in a woman affected by severe osteoporosis and subclinical hypercortisolism due to an adrenal adenoma: A case report

Zavatta Guido , Preiato Valentina Lo , Vandi Giulia , Vicennati Valentina , Di Dalmazi Guido , Pagotto Uberto , Altieri Paola

Context: ß-CTX are considered useful markers of response to denosumab and other anti-resorbtive treatments for osteoporosis. We report an unusual case of a completely absent effect of both denosumab and bisphosphonates on bone resorption markers.Case description: In 2017 a 74-year-old woman sought medical attention at the Endocrinology Unit of Policlinico di Sant’Orsola for the evaluation of an adrenal adenoma associated with osteoporosis. Meno...

ea0041ep23 | Adrenal cortex (to include Cushing's) | ECE2016

Ascending aorta dilatation in primary aldosteronism: a new deleterious consequence of aldosterone excess

Vicennati Valentina , Zavatta Guido , Pagotto Uberto , Casadio Elena , Di Dalmazi Guido , Eleonora Rinaldi , Pasquali Renato

Introduction: Primary aldosteronism (PA) features a higher prevalence of cardiovascular events and renal complications as compared with essential hypertension. The effects of aldosterone excess on ascending aorta have never been investigated in human subjects.Methods: From August 2014 to December 2015, we enrolled forty-seven consecutive PA outpatients who had not undergone surgery of the adrenal mass. Hypercortisolism and pheochromocytoma were excluded....

ea0032p16 | Adrenal cortex | ECE2013

Mortality in long-term follow-up patients with progressively increased patterns of subclinical cortisol hypersecretion

Di Dalmazi Guido , Vicennati Valentina , Paccapelo Alexandro , Pagotto Uberto , Pasquali Renato

Background: Subclinical Cushing’s syndrome (SCS) is defined as alterations in hypothalamic–pituitary–adrenal axis without classic signs or symptoms of glucocorticoid excess. This condition has been associated to increased risk of adverse metabolic and cardiovascular outcomes, independently of other potential risk factors. However, is still not known if this condition could lead to a higher mortality respect to non-secreting adrenal masses (NSA).<p class="abs...

ea0022p40 | Adrenal | ECE2010

Higher cortisol response to glucose load in patient with adrenal adenomas and subclinical Cushing (SC)

Vicennati Valentina , di Dalmazi Guido , Casadio Elena , Repaci Andrea , Pagotto Uberto , Pasquali Renato

Aims: SC can be discovered in 5–20% of the incidentalomas. Subclinical secretion is defined by the failure to suppress plasma cortisol after 1 mg-overnight dexamethasone <50 nmol/l, but there is no agreement in literature. The aim of our study was to evaluate cortisol response to oral glucose tolerance test (OGTT) as potential marker of autonomous activity of these adenomas.Methods: Ninety subjects, 47 females and 43 males, underwent the protoco...

ea0022p426 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Adrenocortical carcinoma (ACC): our experience

Di Dalmazi Guido , Ripani Raffaella , Casadio Elena , Vicennati Valentina , Pagotto Uberto , Pasquali Renato

Aim: ACC is an extremely rare heterogeneous aggressive disease. Clinical presentation are various. The prognosis is very poor. There are limited data to define prognostic markers for survival beyond stage.The aim of this study is to describe the experience of our institution with patients affected by ACC.Material and methods: This study was performed on 13 patients aged between 26 and 76 years, from 1992 to 2009 who turned to our I...

ea0081p29 | Adrenal and Cardiovascular Endocrinology | ECE2022

The changing face of drug-induced adrenal insufficiency in the food and drug administration adverse event reporting system

Raschi Emanuel , Fusaroli Michele , Massari Francesco , Mollica Veronica , Repaci Andrea , Ardizzoni Andrea , Poluzzi Elisabetta , Pagotto Uberto , Di Dalmazi Guido

Importance: Adrenal insufficiency is a life-threatening condition complicating heterogenous disorders across various disciplines, with challenging diagnosis and a notable drug-induced component.Objective: To describe the spectrum and main features of drug-induced adrenal insufficiency through adverse drug event reports received by the Food and Drug Administration (FDA).Design: We conducted a retrospective disproportionality analysi...

ea0081p273 | Adrenal and Cardiovascular Endocrinology | ECE2022

Salivary profiles of cortisol and cortisone in patients with primary adrenal insufficiency under replacement therapy: a pilot study

Tucci Lorenzo , Vicennati Valentina , Magagnoli Matteo , Colombin Giacomo , Coscia Kimberly , Rotolo Laura , Fanelli Flaminia , Pagotto Uberto , Di Dalmazi Guido

Background: Evaluation of steroid replacement therapy (SRT) in adrenal insufficiency (AI) is challenging for the lack of reliable parameters. Measurement of salivary cortisol and cortisone emerged as a non-invasive tool for AI management, however poorly investigated. Aim: To analyse the cortisol and cortisone circadian rhythm in normal controls (NC) and patients with primary AI (PAI) under different SRTs, and to identify useful biomarkers. <p class="...