Searchable abstracts of presentations at key conferences in endocrinology

ea0081oc9.2 | Oral Communications 9: Environmental Endocrinology | ECE2022

Effect of legacy and new generation PFAS on thyrocyte function

De Toni Luca , Di Nisio Andrea , Dall'Acqua Stefano , Sut Stefania , Rocca Maria Santa , Ferlin Alberto , Foresta Carlo

Perfluoroalkyl substances (PFASs) have been claimed as thyroid disrupting chemicals since the exposure to several PFASs was significantly associated with thyroid hormones derangements. Demographics such as sex, age, and disease status likely influence the associations between PFASs exposure and thyroid hormones since major hypothyroidism effects were observed among pregnant women and infants. This study aims to evaluate of the possible impact of legacy and new-generation PFAS ...

ea0081rc12.1 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

RS 2247911 polymorphism of GPRC6A gene and serum undercarboxylated-osteocalcin are associated with testis function

Jawich Kenda , Santa Rocca Maria , Al Fahoum Sahar , Alhalabi Marwan , Di Nisio Andrea , Foresta Carlo , Ferlin Alberto , De Toni Luca

Purpose: Undercarboxylated-OCN (ucOCN), acting on the receptor GPRC6A, was shown to stimulate of testosterone (T) production in Leydig cells in rodents, in parallel with the hypothalamus/pituitary/gonadal axis mediated by luteinizing hormone (LH). Hence, reduced serum ucOCN and/or inactivating gene variants of GPRC6A, are supposed to affect testis function in humans. The aim of this study is to evaluate the association among serum ucOCN, rs2247911 GPRC6A gene polymorphism and ...