Searchable abstracts of presentations at key conferences in endocrinology

ea0028p305 | Steroids | SFEBES2012

Ageing and social isolation increase susceptibility to anxiety in mice lacking 5α-reductase type 1

Di Rollo Emma , Livingstone Dawn , Walker Brian , Andrew Ruth

Glucocorticoid excess is associated with increased anxiety and accelerated cognitive decline. Concentrations of glucocorticoids within tissues, including the brain, are influenced by local metabolism. 5α-Reductase 1 (5αR1), expressed in brain, converts corticosterone to its A-ring reduced metabolites, which have a different spectrum of activities. Here, we investigated if mice homozygous for disrupted 5αR1 alleles (5αR1-KO) experience heightened anxiety and...