Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep684 | Female Reproduction | ECE2016

Usefulness of dynamic Tsh evaluation for diagnosis of subclinical hypothyroidism in luteal deficiency

Mancini Antonio , Giacchi Elena , Saporosi Aurora , Olivieri Giulio , Di Segni Chantal , Marana Riccardo , Pontecorvi Alfredo

Introduction: It is known that thyroid disorders can influence menstrual cycle, but subclinical hypothyroidism (SH), as cause of ovulation disorders and luteal deficiency (LD) in particular,is underestimated. Monitoring women’s cycles, according to the Billings Ovulation Method (BOM), can allow a precise timing for hormonal evaluation and diagnose LD. Usually, a basal TSH value of 2.5 mg/ml is considered as cut-off for a good luteal function, but alone cannot identify all...

ea0037ep468 | Diabetes (complications & therapy) | ECE2015

Different stress hormone response in insulin pump treatment compared with multiple daily injection: preliminary data

Mancini Antonio , Pareo Jacopo , Di Segni Chantal , Raimondo Sebastiano , Rizzi Alessandro , Pitocco Dario

It is known that in type 1 diabetes mellitus (T1DM) continuous subcutaneous insulin infusion (CSII) therapy improves metabolic control and reduces risk of hypoglycaemia in comparison with multiple daily injection (MDI). Metabolic outcomes usually considered are HbA1c, BMI, and inflammatory parameters. However few data are available on pituitary and gonadal hormone responses, which are involved in metabolic processes. In order to study the response of anabolic hormones in patie...

ea0041ep694 | Female Reproduction | ECE2016

Correlation between dehydroepiandrosterone-sulfate levels and markers of bone turnover in hypothalamic amenorrhea

Mancini Antonio , Romualdi Daniela , Raimondo Sebastiano , Di Florio Christian , Di Segni Chantal , Bruno Carmine , Apa Rosanna , Lanzone Antonio

It is known that functional hypothalamic amenorrhea is associated with low bone turnover due to low gonadal homone levels. Estrogens are critical for activation of bone remodelling units, suppression of bone reabsorption, increase of 1-25(OH)Vitamin D receptors expression. Other mechanisms could be operative, including improper diet and unbalanced exercise; however the physiopathology of such a condition is not entirely known. In order to evaluate the correlation between pitui...

ea0037ep1071 | Thyroid (non-cancer) | ECE2015

Could thyroid replacement therapy not be enough to reduce oxidative stress in hypothyroid patients with Down' syndrome? A cohort study

Villani Emanuele Rocco , Onder Graziano , Carfi Angelo , Pagano Francesco , Raimondo Sebastiano , Di Segni Chantal , Silvestrini Andrea , Meucci Elisabetta , Mancini Antonio

Hypothyroidism and autoimmune thyroiditis are common in patients with Down’ syndrome (DS), leading to common prescription of thyroid replacement therapy. On the other hand, thyroid function is involved in oxidative stress (OS) mechanisms. DS is a well-known high OS condition because several genes involved in OS mechanisms map on chromosome 21 and coenzyme Q10, lipophilic antioxidant, could be more correlated with hypothyroidism than TSH in DS people. To investigate relati...

ea0032p87 | Bone and Osteoporosis | ECE2013

Oxidative stress in middle age males with osteoporosis: correlation of hormonal pattern and plasma total antioxidant capacity

Raimondo Sebastiano , Tamburrelli Francesco Ciro , Di Segni Chantal , Persano Mariasara , Festa Roberto , Silvestrini Andrea , Meucci Elisabetta , Pontecorvi Alfredo , Mancini Antonio

Male idiopathic osteoporosis is an underestimated disease, despite its clinical and social importance. The biochemical mechanisms are still poorly understood even if the interaction between genetic factors and hormone environment (especially gonadal steroids and GH) plays a undoubtful role. In previous studies we demonstrated low plasma total antioxidant capacity (TAC) in hypogonadal patients. The aim of this study was to investigate oxidative stress as risk factor for bone fr...

ea0035p653 | Female reproduction | ECE2014

Evaluation of hormonal pattern and index of oxidative stress in normal weight women with polycystic ovary syndrome

Di Segni Chantal , Raimondo Sebastiano , Bergamini Christian , Volta Francesco , Fato Romana , Pareo Jacopo , Cammarano Mauro , Romualdi Daniela , Lanzone Antonio , Pontecorvi Alfredo , Mancini Antonio

It is well known that insulin resistance (IR) is associated with polycystic ovary syndrome (PCOS). Oxidative stress (OS) is, in turn, related to IR, with a vicious cycle. PCOS patients presented higher circulating concentrations of oxidative stress products such as homocysteine, malondialdehyde, an increase of superoxide dismutase and reduction of antioxidants such as glutathione and paraoxonase-1 activity. Most studies however concerned obese PCOS subjects. The physiopatholog...