Searchable abstracts of presentations at key conferences in endocrinology

ea0062cb4 | Additional Cases | EU2019

Propylthiouracil-induced ANCA-associated vasculitis and agranulocytosis in a patient with Graves’ disease

Tomkins Maria , Smith Diarmuid , Agha Amar

42-year-old female with relapsing Graves’ disease treated with propylthiouracil (PTU) presented to the Emergency Department with a two-week history of fevers, night sweats, transient rash, arthralgia and fatigue. Five years previously she presented with Graves’ disease, TSH <0.02 mIU/l, FT4 of 39.8 pmol/l (9–16 pmol/l) and TSH receptor antibody positive with a titre of 11.3 IU/l. Initially treated with carbimazole therapy but developed an urticarial rash, lo...

ea00100wh3.3 | Workshop H: Miscellaneous endocrine and metabolic disorders | SFEEU2024

Idiopathic ketotic hypoglycaemia in an adult male

McDonnell David , Green Deirdre , Smith Diarmuid

Idiopathic ketotic hypoglycaemia is cited as the most frequent cause of hypoglycaemia in childhood but is a rare phenomenon in adults. We present the case of a 72 year man without diabetes presenting to the emergency department with spontaneous symptomatic hypoglycaemia with a glucose of 2.2 mmol/l. On admission he had a normal pituitary profile, negative insulin antibodies, a normal short synacthen test, a negative urine and serum sulphonylurea screen and a normal IGF-II and ...

ea0041ep215 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

TNF related apoptosis inducing ligand (TRAIL) reduces reactive oxygen species production by human aortic endothelial cells exposed to inflammatory stimuli

Forde Hannah , Davenport Colin , Rochfort Keith , Cummins Philip , Smith Diarmuid

Introduction: Accumulating evidence suggests that one of the most significant contributors to endothelial dysfunction is increased oxidative stress. Excessive reactive oxygen species (ROS) generation can have injurious effects within the vasculature including elevated expression of adhesion molecules, stimulation of vascular smooth muscle cell proliferation, and promotion of endothelial cell apoptosis; events which culminate in the formation and progression of atherosclerotic ...

ea0037ep384 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

TRAIL downregulates endothelin 1 and upregulates superoxide dismutase 1 in human aortic endothelial cells under pro-atherorgenic conditions

Forde Hannah , Davenport Colin , Smith Diarmuid , Cummins Phil

Introduction: Increased oxidative stress is associated with endothelial dysfunction in atherosclerosis and cardiovascular diseases (CVD). Evidence suggests that tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of the tumour necrosis factor (TNF) superfamily, may also be involved in the pathogenesis of CVD. Observational studies have demonstrated that serum levels of TRAIL are inversely correlated with severity of coronary artery disease. This concurs ...

ea0086p358 | Reproductive Endocrinology | SFEBES2022

The reproductive years: the experience of women attending routine diabetes care

McDonnell Tara , O'Connor Aisling , Cussen Leanne , Madden Doyle Lauren , Forde Hannah , Smith Diarmuid , O'Reilly Michael W.

Reproductive morbidity is increased in women with diabetes, including a higher prevalence of polycystic ovary syndrome, hypothalamic amenorrhoea and premature ovarian failure. Routine discussion of reproductive and menstrual dysfunction for women with diabetes remains a peripheral feature of clinical consultations. Here we aimed to determine women’s own reproductive care experience. We surveyed women of all ages attending routine diabetes care using a detailed clinical qu...

ea0049ep1041 | Pituitary - Clinical | ECE2017

Idiopathic isolated acquired ACTH deficiency– a case series from the Irish National Pituitary Network

Hannon Anne marie , Smith Diarmuid , Sherlock Mark , Hunter Steven , Thompson Chris

Idiopathic Isolated ATCH deficiency (IIAD) is a rare cause of secondary adrenal insufficiency characterised by ACTH deficiency with otherwise intact pituitary function. Our objective was to describe the presentation, the autoimmune associations and diagnostic findings observed in IIAD. We present a case series of 19 cases of idiopathic Isolated ACTH deficiency which were identified from the National Pituitary Register in Ireland. A chart and biochemical review was performed to...

ea0038p249 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Impact of DAFNE and subsequent CSII therapy on glycaemic control in type 1 diabetes mellitus

Yunus Saba , Forde Hannah , Browne Sonya , Twamley Helen , Fanning Eimear , Smith Diarmuid

Background: Dose adjustment for normal eating (DAFNE) structured education programme is an effective tool in improving glycaemic control in patients with type 1 diabetes while reducing the frequency of hypoglycemic episodes. DAFNE however, does not solve all glucose related problems and patients often request or are recommended continuous subcutaneous insulin infusion (CSII) therapy post DAFNE.Objective: Out of our 370 DAFNE graduates, 46 have subsequent...

ea0038p278 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Comparison of glycaemic control in patients with type-1 diabetes mellitus on CSII therapy with different basal rates

Yunus Saba Yunus , Forde Hannah , Browne Sonya , Moore Anne , Fanning Eimear , Smith Diarmuid

Background: There are very few studies comparing glycaemic control in patients with different basal rates on Continuous Subcutaneous Insulin Infusion therapy (CSII), so the ideal number of basal rates for a patient is not clear.Objective: To compare the glycaemic control between patients with different basal rates.Methods: Data were collected from hospital’s database and by contacting patients via phone....

ea0031p18 | Bone | SFEBES2013

Predictors of low bone mineral density in an Irish cystic fibrosis (CF) cohort

McEnery Tom , Glynn Nigel , Gunaratnam Cedric , McElvaney Noel , Smith Diarmuid , McHenry Claire

Increased life expectancy in patients with CF has brought about novel challenges in their care. Osteoporosis in CF is associated with significant morbidity and is an exclusion criterion for lung transplantation. Recent evidence suggests an association between dysglycaemia and low bone mineral density (BMD). We aimed to determine predictors of bone loss in a cohort of CF patients attending a tertiary referral centre and, in particular, if dysglycaemia is linked with low BMD.</p...

ea0015p233 | Pituitary | SFEBES2008

Defining the serum prolactin concentration threshold in stalk compressing non-prolactinoma pituitary adenomas

O'Sullivan Eoin , Woods Conor , Glynn Nigel , Behan LucyAnn , Crowley Rachel , Smith Diarmuid , Agha Amar

Differentiation between non functioning pituitary macroadenomas (NFPA) and prolactinomas may be difficult as hyperprolactinaemia can also be present at diagnosis in NFPA cases due to pituitary stalk compression (disconnection hyperprolactinaemia). Some authors suggested that prolactin >2,000 mIU/l is almost diagnostic of a prolactinoma, while others use a higher cut-off of >5000 mIU/l. Our aim was to identify the level of prolactin above which a prolactinoma was more l...