Searchable abstracts of presentations at key conferences in endocrinology

ea0019p194 | Endocrine tumours and neoplasia | SFEBES2009

Essential role of TRPC channels in human ovarian cancer cell proliferation

Wake J , Dickerson E , Avazzadeh S , Watson NM , Saurabh R , Atkin SL , Xu SZ

The transient receptor potential canonical channels (TRPC) are a new family of Ca2+-permeable cationic channels controlling the Ca2+ influx response to the activation of the G-protein coupled receptor or the depletion of the internal Ca2+ store, which is related to the cellular signalling mechanisms of many hormones or growth factors. The role of TRPC channels in cancer development is still unclear. Therefore, we aimed to investigate the expres...