Searchable abstracts of presentations at key conferences in endocrinology

ea0037gh1 | The Geoffrey Harris Prize Lecture | ECE2015

Understanding energy sensors, understanding neuroendocrine function

Dieguez Carlos

The question on how cells, tissues and organisms are able to detect energy/nutrient availability has been the focus of research for many years. Data gleaned recently have identified different nutrient-sensing circuits implicated in the regulation of different homeostatic process. Furthermore, there has been a steady increase in our knowledge regarding the cellular and molecular mechanisms involved in nutrient detection and integration. In particular, this has allowed for a bet...

ea0037gh1biog | The Geoffrey Harris Prize Lecture | ECE2015

Geoffrey Harris Prize Winner UK

Dieguez Carlos

This prestigious prize is intended for established workers in the field of basic and clinical neuroendocrinology and is generously supported by Ipsen. This year’s recipient is Prof. Carlos Dieguez. The prize will be presented as part of the ECE 2015 opening ceremony where Prof. Dieguez will deliver his lecture. Prof. Dieguez will also deliver two other lectures at future ESE scientific meetings. Further information can be found at <a href="

ea0081oc10.6 | Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Opposite actions of LEAP-2 and ghrelin in energy homeostasis

Masa Sabela Casado , De Oliveira Diz Tadeu , Miguens Marta Varela , Gonzalez Carlos Dieguez , Carro Sulay Tovar

Liver-expressed antimicrobial peptide 2 (LEAP-2) has been recently characterized as an endogenous GHSR1a antagonist. LEAP-2 is produced mainly in the liver, and it was described that an acute ghrelin administration blocks food intake, GH release and normalize glucose levels during chronic caloric restriction. For this reason, it could be considered as a key endocrine factor in the regulation of systemic energy metabolism. Nevertheless, the exact mechanism of action is still un...

ea0032p726 | Obesity | ECE2013

The lack of Nur77 affects energy and glucose metabolism in females fed on high fat diet

Sieira Sonia Perez , Martinez Gloria , Porteiro Begona , Lopez Miguel , Vidal Anxo , Nogueiras Ruben , Dieguez Carlos

Nur77 is an orphan nuclear receptor included in the NR4A family. This protein has been studied as a transcriptional regulator of glucose metabolism in different tissues. We aimed to investigate the endogenous role of Nur77 on energy and metabolic homeostasis. For this purpose, we used male and female Nur77-deficient mice and their wild-type littermates. We challenged them to standard diet and high fat diet, and analyzed different parameters involved in energy balance (food int...

ea0016s23.4 | Towards a better understanding of hypothalamic–pituitary disorders | ECE2008

Cell cycle control and proliferative diseases of the pituitary

Quereda Victor , Garcia-Lavandeira Montse , Dieguez Carlos , Alvarez Clara , Malumbres Marcos

The importance of cell cycle regulation in pituitary biology has been suggested from the fact that many gene-targeted mouse models of cell cycle mutations develop diverse pituitary pathologies. The retinoblastoma protein (pRb)/cyclin-dependent kinase 4 (Cdk4) pathway, one of the major mitogen-sensor routes in the cell, seems to be critical in the control of pituitary cell proliferation. Both inactivation of pRb or hyperactivation of Cdk4 result in pituitary hyperplasias or tum...

ea0016p69 | Bone and calcium | ECE2008

Bone metabolism in hypothalamic obesity

Doknic Mirjana , Pekic Sandra , Miljic Dragana , Stojanovic Marko , Djurovic Marina , Dieguez Carlos , Casanueva Felipe , Popovic Vera

Obesity protects from osteoporosis. Bone remodeling and energy metabolism could be regulated by the adipocyte-derived hormone, leptin acting on osteoblasts though hypothalamic pathways. Hypothalamic lesions cause obesity. Since most of these patients are also hypopituitary with low IGF1 which could affect bone metabolism the aim of our study was to investigate whether obesity would protect them from osteoporosis.Three groups of patients were studied: (1)...

ea0016p535 | Obesity | ECE2008

Postnatal determination of ghrelin secretion levels and sexual dimorfism in the rat

Al-Massadi Omar , Gonzalez Carmen Ruth , Pardo Maria , Dieguez Carlos , Casanueva Felipe , Seoane Luisa Maria

Ghrelin is a pleiotropic hormone characterized mainly by its strong orexigenic action and its role as GH secretagogue.Age-related level variation of this hormone has been previously shown in different studies centred in mARN expression and in its plasma levels; however there is no data about its secretion directly from the stomach although this is the main ghrelin producing organ.Objectives: To determine the levels of ghrelin in th...

ea0037oc7.2 | Neuroendocrinology and pituitary-basic | ECE2015

KLF4 in hypothalamus regulates leptin homeostatic effects through AgRP

Sanchez-Rebordelo Estrella , Imbernon Monica , Gallego Rosalia , Gandara Marina , Lear Pamela , Lopez Miguel , Dieguez Carlos , Nogueiras Ruben

Introduction: Krüpel-like factor 4 (KLF4) is a zinc-finger-type transcription factor expressed in a range of tissues that plays multiple functions. KLF4 is expressed in neural stem cells and is critical to neuronal differentiation. Recent evidence suggests that KLF4 also plays an important role in the central regulation of energy balance. In vitro studies show that KLF4 is a transcriptional regulator of agouti–related protein (AgRP), essential to the hyperph...

ea0032p364 | Diabetes | ECE2013

Heterozygous deficiency of endoglin decreases insulin and hepatic triglyceride levels during high fat diet

Beiroa Daniel , Amparo Romero-Pico , Carmen Langa , Carmelo Bernabeu , Miguel Lopez , Lopez-Novoa Jose M , Ruben Nogueiras , Carlos Dieguez

Introduction: Endoglin is a transmembrane auxiliary receptor for transforming growth factor-β (TGF-β) that is predominantly expressed on proliferating endothelial cells. It plays a wide range of physiological roles but its importance on energy balance or insulin sensitivity has been unexplored.Material and methods: Heterozygous deficient mice (HZ) were fed standard chow or high fat diet during 16 weeks. Blood glucose levels were measured after ...

ea0063p266 | Pituitary and Neuroendocrinology 1 | ECE2019

Antitumor effects of growth hormone-releasing hormone (GHRH) antagonists in ACTH and GH-secreting pituitary adenoma cell lines

Fanciulli Alessandro , Gesmundo Iacopo , Gamba Giacomo , Castano Justo P , Luque Raul M , Alvarez Clara V , Dieguez Carlos , Chiara Zatelli Maria , Ghigo Ezio , Schally Andrew V , Granata Riccarda

Pituitary neuroendocrine tumors (PitNETs) are mostly benign lesions originating from the anterior pituitary and represent 10–15% of all the intracranial neoplasms. PitNETs can be classified in non-secretory, clinically non-functioning pituitary adenomas (NFPAs), and secretory, comprising prolactin (PRL), growth hormone (GH) and adrenocoticotropic hormone (ACTH) PitNETs. Surgical resection is the first line treatment for PitNETs, whereas chemotherapy and radiotherapy are p...