Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.03.04 | Adrenal (2) | ECE2015

Prolactinoma and primary aldosteronism: is there a causal link?

Williams Tracy Ann , Dietz Anna , Beuschlein Felix , Mulatero Paolo , Reincke Martin

Introduction: We report the largest case series of concomitant prolactinoma and aldosterone-producing adenoma (APA), diagnosed in four patients from the German Conn Registry and in three patients at the Hypertension Unit, University of Torino. A disproportionate number (five out of seven) presented with macro-prolactinomas indicating that elevated prolactin (PRL) concentrations may play a role in APA formation. Further, increased expression of PRLR in the zona glomeru...

ea0041ep5 | Adrenal cortex (to include Cushing's) | ECE2016

Paradoxical worsening of lipid metabolism after successful treatment of primary aldosteronism

Adolf Christian , Asbach Evelyn , Dietz Anna , Hahner Stefanie , Quinkler Marcus , Rump Lars Christian , Bidlingmaier Martin , Treitl Marcus , Hallfeldt Klaus , Beuschlein Felix , Reincke Martin

Primary aldosteronism (PA) describes the most frequent cause of secondary arterial hypertension. Aldosterone itself represents a BP-independent cardiovascular risk factor associated with increased rates of morbidity and mortality. Recently a worsening of lipid metabolism after treatment has been described.Objective: Our aim was to analyse changes in lipid parameters according to treatment outcome in PA patients. Data of 215 consecutive PA patients with u...

ea0037gp.29.03 | Endocrine tumours and neoplasia – Adrenal Tumour | ECE2015

Immunoexpressions of CYP11B2 and HSD3B2 in genetically characterised aldosterone producing adenomas

Gebhard Christian , Rhayem Yara , Dietz Anna , Riester Anna , Hantel Constanze , Schuster Marion , Strom Tim M , Gomez-Sanchez Celso , Reincke Martin , Beuschlein Felix

Primary aldosteronism caused by aldosterone-producing adenoma (APA) or bilateral adrenal hyperplasia is the most prevalent cause of secondary hypertension. Somatic mutations of KCNJ5, ATP1A1, CACNA1D and ATP2B3 have been shown to be involved in the formation of APA. We studied the immunoexpressions of CYP11B2 and HSD3B2, the rate-limiting enzyme for aldosterone production and the prevalent isoform of β-HSD found in APA respectively, and...

ea0037ep77 | Adrenal cortex | ECE2015

Prevalence of neoplasms in patients with primary aldosteronism

Lang Katharina , Weber Katrin , Quinkler Marcus , Dietz Anna , Wallaschofski Henri , Hannemann Anke , Vonend Oliver , Willenberg Holger , Reincke Martin , Allolio Bruno , Hahner Stefanie

Context: Primary aldosteronism (PA) is the most common cause of secondary hypertension. Aldosterone excess can cause oxidative stress and respectively DNA damage in vitro and in vivo and increased levels of oxidative stress have been demonstrated in PA patients. Single case reports describe a coincidence of PA with renal cell carcinoma (RCC) and other tumours. However, so far no data on the prevalence of benign and malignant neoplasms in patients with PA exis...

ea0041gp9 | Adrenal | ECE2016

Is steroid profiling using LC-MS/MS useful in the diagnostic work-up of primary aldosteronism?

Williams Tracy A. , Lenders Jacques W.M. , Peitzsch Mirko , Dekkers Tanja , Dietz Anna S. , Rump Lars C. , Willenberg Holger S. , Treitl Marcus , Bidlingmaier Martin , Beuschlein Felix , Deinum Jaap , Eisenhofer Graeme , Reincke Martin

Introduction: Primary aldosteronism (PA) is mainly caused by unilateral aldosterone-producing adenomas (APA) or bilateral adrenal hyperplasia (BAH). Subtype differentiation relies on the invasive and technically challenging adrenal venous sampling (AVS). We recently demonstrated the potential utility of peripheral plasma steroid profiling by LC-MS/MS to distinguish APA and BAH. We tested the following hypotheses: first, if steroid profiling in combination with AVS, effectively...

ea0041gp10 | Adrenal | ECE2016

PRKACA somatic mutations are rare in aldosterone-producing adenomas.

Rhayem Yara , Perez-Rivas Luis Gustavo , Dietz Anna , Bathon Kerstin , Gebhard Christian , Riester Anna , Mauracher Brigitte , Gomez-Sanchez Celso , Schwarzmayr Thomas , Calebiro Davide , Strom Tim M. , Reincke Martin , Beuschlein Felix

Aldosterone-producing adenomas (APAs) are the most frequent cause of primary aldosteronism (PA). Somatic mutations of KCNJ5, ATP1A1, CACNA1D and ATP2B3 are involved in APAs formation while CTNNB1 and GNAS somatic mutations have been described in both APAs and in cortisol-producing adenomas (CPAs). In contrast, mutations of PRKACA coding for the catalytic subunit of protein kinase A have been yet only identified in ...

ea0038oc1.6 | Early Career Oral Communications | SFEBES2015

Urine steroid metabolomics as a diagnostic tool in primary aldosteronism

Lang Katharina , Beuschlein Felix , Biehl Michael , Dietz Anna , Riester Anna , Hughes Beverly A , O'Neil Donna M , Hahner Stefanie , Quinkler Marcus , Lenders Jacques W , Shackleton Cedric H L , Reincke Martin , Arlt Wiebke

Introduction: The regular diagnostic workup for primary aldosteronism (PA) can be very demanding and involves multiple invasive as well as time and cost intensive diagnostic tests. Here we have explored the value of urinary steroid metabolome analysis in the diagnosis and differential diagnosis of PA. Previously, urinary 3α,5β-tetrahydroaldosterone (THAldo) has been suggested as a reliable screening test for PA and serum 18-oxocortisol and 18-hydroxycortisol have bee...