Searchable abstracts of presentations at key conferences in endocrinology

ea0081p661 | Pituitary and Neuroendocrinology | ECE2022

Metyrapone vs osilodrostat in the short-term therapy of endogenous Cushing’s syndrome: results from a retrospective single center analysis

Detomas Mario , Altieri Barbara , Deutschbein Timo , Fassnacht Martin , Dischinger Ulrich

Background: Although surgery is considered the first-line treatment for patients with endogenous Cushing’s syndrome (CS), medical therapy is often required to control severe hypercortisolism. Metyrapone and osilodrostat are inhibitors of 11β-hydroxylase that have not been directly compared yet.Methods: Retrospective analysis of patients with adrenocorticotropin (ACTH)-dependent and ACTH-independent CS treated with metyrapone or osilodrostat (as...

ea0073aep826 | Late Breaking | ECE2021

The promising role of Agouti related peptide in the differentiation of ACTH-independent Cushing syndrome

Detomas Mario , Altieri Barbara , Fassnacht Martin , Dischinger Ulrich

BackgroundAgouti related peptide (AgRP) is a neuropeptide, produced by the hypothalamus and by the adrenal glands. AgRP is an antagonist of proopiomelanocortin (POMC) and its principal role is to stimulate appetite. Although current evidences suggest that AgRP levels are influenced by glucocorticoids, it is still not clear, whether they depend on adrenocorticotropic hormone (ACTH) or cortisol. One of the aims of this study was to address this issue. Furt...

ea0070aep286 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Liraglutide and PYY3–36 combination therapy partially achieves the metabolic benefits of Roux-en-Y gastric bypass surgery in diet-induced obese rats

Dischinger Ulrich , Hasinger Julia , Königsrainer Malina , Corteville Carolin , Otto Cristoph , Fassnacht Martin , Hankir Mohamed , Seyfried Florian

Background: Circulating levels of the appetite-suppressing and glucoregulatory gut hormones glucagon-like peptide 1 (GLP-1) and peptide tyrosine tyrosine 3–36 (PYY3–36) are markedly increased after Roux-en-Y gastric bypass surgery (RYGB), which may contribute to some of its profound metabolic benefits in morbidly obese individuals.Objectives: To directly compare the metabolic effects of chronic systemic administration of the clinic...

ea0070aep426 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Effects of bariatric surgery in patients with craniopharyngioma

Dischinger Ulrich , Kötzner Laura , Koschker Ann-Cathrin , Haas Christina , Herrmann Martin , Fassnacht Martin , Seyfried Florian

Effects of Bariatric Surgery in Patients with CraniopharyngiomaObjectives: The prime objective of this study is the identification of the limiting factors of metabolic surgeries on weight reduction in patients with craniopharyngioma (CP) and consecutive hypothalamic obesity (HO).Patients: As of now, 37 patients were included, of which5 patients presented with HO and earlier bariatric surgery (mean BMI 50.44 kg/m2), ...