Endocrine Abstracts

The use of continuous glucose monitoring (CGM) by individuals with type 1 diabetes (T1D) has revolutionized the management of hypoglycemia. Previously, hypoglycemia was defined solely by a glucose threshold. However, CGM has introduced the additional dimension of time. International consensus guidelines now define CGM-detected hypoglycemia as glucose levels below the hypoglycemic threshold for at least 15 minutes. Using this definition, a high proportion (>60%) of hypoglyc...

Duodenopancreatic neuroendocrine tumours (dpNETs) affect more than 90% of patients with Multiple Endocrine Neoplasia type 1 (MEN1) by age of 70. Insulinomas are the second most common functioning dpNET encountered in this setting. We present the case of a 56 year-old woman with genetically confirmed MEN1 in whom non-functioning pNETs transformed into insulinomas, seven years after being diagnosed with MEN1 syndrome and pNETs. The patient was referred to the neuroendocrine clin...

We conducted a retrospective study examining the prevalence of abnormal liver function tests (LFTs) in a diabetic population attending a tertiary referral centre and APRI and FIB4 scores were also calculated where possible. APRI and FIB4 scores can be used to estimate degree of liver fibrosis. APRI score >1 has 76% sensitivity, 72% specificity for predicting cirrhosis. APRI score >0.7 has 77% sensitivity, 72% specificity for predicting significant fibrosis. A FIB4 scor...

Introduction: Hypoglycaemia is a key barrier to physical activity in people with diabetes. We explored the association between hypoglycaemia fear and daily step-count in adults with type 1 diabetes (T1D) and insulin treated type 2 diabetes (T2D). Methods: Participants from the Hypo-METRICS study wore a Fitbit Charge 4 activity monitor, blinded continuous glucose monitor and reported episodes of hypoglycaemia on a smartphone app for 10-weeks. Participants...

Background: Impaired awareness of hypoglycaemia (IAH) is associated with impaired psychological health in people living with type 1 diabetes (T1D). We explored the differences in anxiety, depression and diabetes distress according to hypoglycaemia awareness in people living with insulin-treated type 2 diabetes (T2D).Methods: This analysis included 321 T2D participants from the Hypo-METRICS study. Participants completed the General Anxiety Disorder-7 (GAD...