Searchable abstracts of presentations at key conferences in endocrinology

ea0044p132 | Neoplasia, cancer and late effects | SFEBES2016

Sparsely granulated somatotroph adenomas display aspects of epithelial-mesenchymal transition

Dix Kathryn , Grossman Ashley , Ansorge Olaf , Larkin Sarah

Somatotroph adenomas (SA) causing acromegaly exist as two major pathological variants: densely and sparsely granulated, according to the number and distribution of growth-hormone-containing secretory granules. These variants are increasingly recognised by neuropathologists and endocrinologists, but the consequences for tumour behaviour and patient outcome remain to be defined. Sparsely granulated SAs are associated with younger, female patients and are more invasive and prolif...