Searchable abstracts of presentations at key conferences in endocrinology

ea0025p246 | Pituitary | SFEBES2011

SIADH of cancer: rapid diagnostic evaluation using copeptin as a marker of AVP

Dixit Kashinath , Morgenthaler Nils , Brabant Georg

With the advent of vaptans as a therapeutic option, rapid and precise diagnosis of SIADH is essential. SIADH due to paraneoplastic stimulation of AVP is an expected but not the only cause of hyponatraemia in cancer patients. Therefore a precise evaluation of the cause of hyponatraemia is necessary before any therapeutic approach. Using Copeptin, a stable marker of AVP, which is stoichiometrically released with AVP, we evaluated 49 patients with hyponatremia due to various form...

ea0022oc3.2 | Pituitary | ECE2010

Copeptin, an arginine vasopressin (AVP) marker, as a diagnostic aid in SIADH of cancer

Dixit Kashinath , Morgenthaler Nils , Brabant Georg

Copeptin is a stable AVP marker and stoichiometrically released with AVP. It closely reflects changes in water balance. Its stimulation in severe stress has recently has been suggested in various pathophysiological conditions including myocardial infarction and stroke. Paraneoplastic stimulation of AVP/copeptin is expected in patients with cancer leading to hyponatraemia due to SIADH.Here, we evaluated copeptin levels in 50 patients with hyponatraemia du...

ea0025p19 | Bone | SFEBES2011

Cervical cord compression in a patient with Paget's disease and primary hyperparathyroidism: a diagnostic challenge

Ho Jan Hoong , Dixit Kashinath , Golash Aprajay , Howell Simon

Case: A 77-year-old man was admitted with a pathological fracture of the right femur, which required intramedullary nailing. He had previously been diagnosed with Paget’s disease affecting the right femur and also hyperparathyroidism with a large parathyroid adenoma on Sestamibi scan which had been managed at another hospital. On this admission, his corrected calcium was 2.79 (2.15–2.55) mmol/l, PTH 643 (15–65) pg/ml and alkaline phosphatase 258 (30–130) U/...

ea0021p292 | Pituitary | SFEBES2009

Circadian and pulsatile secretion of copeptin, an arginine vasopressin (AVP) marker, argues against a physiological role of AVP in cortisol release

Darzy Ken , Dixit Kashinath , Shalet Stephen , Morgenthaler Nils , Brabant Georg

Copeptin is a stable AVP marker and stoichiometrically released with AVP. It closely reflects changes in water balance. Its stimulation in severe stress has recently has been suggested for the early diagnosis of myocardial infarction but clear definition of the physiological variability is necessary. Here, we studied the pulsatile and circadian variation in healthy individuals and compared copeptin to cortisol rhythms.Copeptin levels were sampled every 2...

ea0015p167 | Endocrine tumours and neoplasia | SFEBES2008

Endocrine manipulation to treat aggressive angiomyxoma

Dixit Kashinath , O'dwyer Sarah , Trainer Peter , Brabant Georg , Shalet Stephen

Aggressive angiomyxoma (AA) is a rare mesenchymal tumor which is more common in females, occurring predominantly in the pelvi-perineal region. It tends to be locally aggressive with high recurrence after primary excision. The majority of these tumors are positive for oestrogen and progesterone receptors. Hence hormonal manipulation provides the possibility of effective treatment.Since 2005, we have been treating two female patients with AA medically (see...

ea0013p240 | Neuroendocrinology and behaviour (including pituitary) | SFEBES2007

Traumatic brain injury and hypopituitarism

Rao-Balakrishna Prasanna , Dixit Kashinath , Sudagani Jaidev , Kearney Tara

Road traffic accidents resulting in traumatic brain injuries are increasingly common. Patients are often males in their third decade. Many of these patients persist to have various symptoms even after recovery from the acute phase, which tend to be diagnosed as post concussion syndromes. Interest has increased of late in Post traumatic hypopituitarism. We report two patients with head injuries with endocrine insufficiencies.A 21 year male was hit by a ca...

ea0028p368 | Thyroid | SFEBES2012

An audit on the management of hypothyroidism in pregnancy

Ho Jan Hoong , Dixit Kashinath , Abdo Khalil , Howell Simon , Kaushal Kalpana

Introduction: Maternal hypothyroidism is associated with an increased risk of complications both to the pregnant mother and the developing fetus. The 2007 American Endocrine Society Guidelines recommend a rapid titration of thyroxine dose to attain a target TSH concentration of ≤2.5 µU/mL in the 1st trimester (≤3 µU/mL in the 2nd and 3rd trimesters). Objectives Our aims were to assess the adequacy of thyroxine replacement in pregnant women with hypothyroi...

ea0015p177 | Endocrine tumours and neoplasia | SFEBES2008

Thalidomide therapy for metastatic adrenal carcinoma

Dixit Kashinath , Shablak Alaaeldin , Jacob Koshy , Walmsley David , Hawkins Robert , Trainer Peter

Adrenocortical carcinoma are rare, highly vascular tumours with a generally poor prognosis. We have studied the use of the antiangiogenic drug, thalidomide (TH), in 6 patients with metastatic adrenocortical carcinoma (5 patients had adrenalectomy and one patient was inoperable#). The response to thalidomide treatment is summarized in the following Table. Assuming the residual/metastatic tumours to have a spheroidal form, the tumour volume (V) was calculated using the eq...