Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1791 | Thyroid cancer | ICEECE2012

Desmoplastic stromal reaction and extrathyroidal invasion predict lymph node involvement in sporadic macro medullary thyroid cancer

Berdelou A. , Aubert S. , Pattou F. , Pigny P. , Gnemmi V. , Carnaille B. , D'Herbomez M. , Wemeau J. , Do Cao C.

Background: Locoregional nodal metastases are the first step of tumor spread in MTC and have been shown to be a prognostic factor for survival. Neither palpation nor neck ultrasound can estimate nodal staging accurately.Aim: To identify predictive factors for LNI in MTC through a retrospective study on 142 consecutive patients operated in Lille University Hospital between 1995 and 2010.Methods: Analyses were carried on 54 patients ...

ea0011p442 | Endocrine tumours and neoplasia | ECE2006

Biological diagnosis of 63 pheochromocytomas and/or paragangliomas

d’Herbomez M , Bauters C , Rouaix N , Forzy G , Do Cao C , Carnaille B , Wemeau JL

Pheochromocytomas are neuroendocrine tumors able to synthesise cathecholamines as well as to metabolise them in metanephrines (NM,M). We assayed Adrenaline, NorAdrenaline, Dopamine and metanephrines in serum (p) and urine (u), and the chromogranin A. We measured 11 parameters (Ap, Au, NAp, NAu, Du, MNp, MNu, Mp, Mp, 3Metu, CgA). Catecholamines and metanephrines were performed using HPLC with electrochemical detection, and CgA with an immunometric as...

ea0011p816 | Thyroid | ECE2006

Prognostic factors for persistent or recurrent disease from a series of 81 patients with oncocytic thyroid carcinoma

Do Cao C , Mirghani H , Wemeau JL , Leteurtre E , d’Herbomez M , Marchandise X , Proye C

Much controversy persists over aggressiveness of oncocytic thyroid carcinoma (OTC) and its optimal treatment. The study purpose was to determine prognostic factors for persistent or recurrent disease (PRD) and discuss therapeutic directions.We reviewed the medical records of 81 consecutive patients with OTC among a total of 1729 (4.7%) epithelial thyroid cancers, operated from 1983 to 2003 in our center. Follow-up information was updated. Age ranged from...

ea0026p30 | Adrenal cortex | ECE2011

Is plasma mitotane level >30 mg/l a serious adverse event in patients with adrenocortical carcinoma (ACC)?: a retrospective analysis of the French COMETE network

Mauclere-Denost S M D , Tabarin A T , Drui D D , Chaillous L C , Salenave S S , Leboulleux S L , Chabre O C , Do-Cao C D C , Dubourg H D , Cuvelier M L C , Young J Y , Baudin E B

Background: Mitotane antitumor efficacy is related to plasma levels. Objective responses have been associated with mitotane plasma levels >14 mg/l. However, high plasma levels >20 or >30 mg/l are at higher risk of toxicity, especially neurotoxicity. National-based survey is lacking to evaluate the frequency and severity of high mitotane plasma levels. Our aim was to retrospectively describe serious adverse events (SAE).Methods: Mitotane plasm...

ea0029oc7.1 | Adrenal Clinical | ICEECE2012

Progression-free survival without treatment of malignant pheochromocytoma and paraganglioma at one year

Hescot S. , Leboulleux S. , Amar L. , Borget I. , Vezzosi D. , Libe R. , Niccoli P. , Borson-Chazot F. , Do Cao C. , Tabarin A. , de la Fouchardiere C. , Raingeard I. , Chougnet C. , Gimenez-Roqueplo A. , Young J. , Bertherat J. , Wemeau J. , Bertagna X. , Schlumberger M. , Plouin P. , Baudin E.

Pheochromocytoma and paraganglioma are defined as malignant by the occurence of metastasis in extra paraganglionic sites. The natural evolution of these tumors remains unknown.The aim of our retrospective study was to define the progression-free survival (PFS) of untreated Malignant Pheochromocytoma and Paraganglioma (MPP) at 12 months (12 m-PFS) and to look for prognostic markers of 12 m-PFS. We analyzed clinical parameters of patients followed within 8...

ea0029p1786 | Thyroid cancer | ICEECE2012

Is thyroid cancer recurrence risk increased after transplantation?

Tisset H. , Kamar N. , Faugeron I. , Pouteil-Noble C. , Klein M. , Frimat L. , Mourad G. , Drui D. , Do Cao C. , Vanthygem M. , Noel C. , Leenhardt L. , Rodien P. , Bonichon F. , Morelon E. , Leboulleux S. , Bournaud C. , Kelly A. , Niccoli P. , Schlumberger M. , Borson-Chazot F.

Context: An increased mortality by cancer is reported in grafted patients.Objective: This multicentric study aimed to investigate whether the prognosis of thyroid cancer was modified by transplantationResults: Sixty nine patients (35 M/34 F; median age 41 years) with a history of both thyroid cancer and transplantation were recruited via specialized networks (TUTHYREF and DIVAT). Evolution and outcome were retrospectively analyzed ...

ea0026p70 | Endocrine tumours and neoplasia | ECE2011

First prognostic analysis of stage III adrenocartical carcinoma patients after complete resection: a retrospective French Multicentric Study from the INCA-COMETE network

Do Cao C , Leboulleux S , Borget I , Bertherat J , De la Fouchardiere C , Hecart A C , Caron P , Tabarin A , Niccoli P , Rohmer V , Drui D , Schillo F , Raingeard I , Young J , Ghuzlan A , Borson-Chazot F , Bertagna X , Pattou F , Wemeau J L , Francis Z , Libe R , Aubert S , Baudin E

Objective: To assess outcome of stage IIIĀ–ENSAT adrenocortical carcinoma (ACC) patients after complete macroscopic resection and prognostic factors for disease-free survival (DFS) and overall survival (OS).Methods: A retrospective review of 68 stage III ACC patients treated surgically between 1994 and 2009 in the French COMETE network was performed. Characteristics of patients were reviewed by a single investigator as well as the Weiss score by expe...