Endocrine Abstracts

Background: Obesity can damage kidney via directly, through the production of pro-inflammatory adipocytokines, and indirectly due to systemic complications. Several strategies are available for weight loss (lifestyle, anti-obesity drugs and surgery therapy), but there are no guidelines to manage subjects with obesity and chronic kidney disease. Very low-calorie ketogenic diet (VLCKD) is an increasingly used tool for weight loss in subjects with obesity. Thus, we aimed to inves...

Introduction: Currently, patients with type 1 diabetes (T1D) have the option of being treated with Hybrid Closed Loop (AHCL) systems, which allow insulin delivery to be modulated according to glycemic values. These systems do not allow any kind of anthropometric or laboratory characteristics to be used to enhance the devices’ capabilities. Thus, the aim of our study was to investigate the efficacy of AHCL systems in subjects with T1D and with obesity compared to normal-we...

Introduction: A higher adherence (HA) to the Mediterranean Diet (MD) is associated to a lower risk of developing type 2 diabetes (T2DM). However it is less clear if this is caused by a “food cluster” (FC) or a single MD food effect on the insulin-resistance (IR) and/or on the insulin-secretion (IS).Aim: This study investigated the association between MD adherence, IR and IS, indirectly measured, in subjects affected by obesity without diabetes ...

Introduction: The VLCKD is an established diet regimen with positive metabolic effects. Based on that, it was hypothesized that VLCKD could also have positive effects on glucose metabolism and insulin resistance, as well as obesity. Specifically, we aimed to investigate the efficacy of VLCKD on glucose metabolism in subjects with obesity compared to Mediterranean Diet.Methods: In this cross-sectional study anthropometric parameters (weight, height and wa...

Objective: Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder. Recently in the context of obesity, which often coexists with PCOS, it has been highlighted the role of chronotype as risk factor for obesity-related cardiometabolic complications. Given the importance of chronotype categories in the context of metabolic diseases and being PCOS characterized by metabolic derangements, we aimed to investigate the prevalence of chronotype categories in wome...