Searchable abstracts of presentations at key conferences in endocrinology

ea0063p500 | Calcium and Bone 2 | ECE2019

Body mass index is a biomarker of resistance to active vitamin D but not to calcium supplementation, in patients with hypoparathyroidism

Tecilazich Francesco , Formenti Anna Maria , Frara Stefano , Resmini Eugenia , Doga Mauro , Giubbini Raffaele , Giustina Andrea

Background: Persistent Hypoparathyroidism (PH) is a condition characterized by inappropriately low concentrations of PTH that lead to hypocalcemia. The treatment cornerstones of PH are calcium and calcitriol supplementation; however, several patients do not achieve adequate control of the disease under this conventional therapy. Notably, no biomarker of risk of ‘resistance’ has yet been identified. Based on the fact that obesity alters the vitamin D-calcium homeostas...

ea0056p819 | Pituitary - Clinical | ECE2018

Age and severity of hyperthyroidism are determinants of thoracic vertebral fractures in patients with TSH-secreting pituitary adenoma

Frara Stefano , Losa Marco , Doga Mauro , Formenti Anna Maria , Mortini Pietro , Mazziotti Gherardo , Giustina Andrea

Introduction: Osteoporosis and vertebral fractures (VFs) commonly occur in overt and subclinical primary hyperthyroidism. In this clinical setting, bone damage is caused by the direct effects of thyroid hormone in excess on bone remodeling, although there is also evidence that low thyrotropin (TSH) values may play a role in driving fracture risk. In fact, TSH was shown to have direct inhibitory effects on osteoclastogenesis and bone resorption. Based on these data, one could a...

ea0081p35 | Calcium and Bone | ECE2022

Vertebral Fractures at hospitalization predict impaired respiratory function at follow-up of COVID-19 survivors

Di Filippo Luigi , Compagnone Nicola , Frara Stefano , Allora Agnese , Doga Mauro , Rovere-Querini Patrizia , Cremona George , Giustina Andrea

Morphometric-Vertebral Fractures (VFs), which were widely demonstrated to reduce overall-survival and respiratory function in the general population, have been recently reported to be highly prevalent in COVID-19 patients. Emerging data show negative respiratory sequelae at long-term follow-up in COVID-19 survivors. The aim of this study is to evaluate the VFs influence on respiratory function of COVID-19 survivors. We included COVID-19 patients admitted at San Raffaele-Hospit...

ea0081p566 | Calcium and Bone | ECE2022

High prevalence of thoracic vertebral fractures in patients with medullary thyroid cancer

Di Filippo Luigi , Albanese Lucrezia , Castellino Laura , Doga Mauro , Formenti Anna Maria , Frara Stefano , Perticone Francesca , Giustina Andrea

Medullary thyroid cancer (MTC) is a rare malignancy of the thyroid gland. MTCs originate from thyroid-C cells and account for 2-4% of all thyroid neoplasms. Originating from thyroid-C cells, the main secretory product of MTCs is calcitonin, used as sensitive and specific MTC-biomarker. Calcitonin is a hormone known to participate in calcium-bone metabolism suppressing bone-resorption by inhibiting the activity of osteoclasts, and inhibiting the kidney reabsorption of calcium a...

ea0063p1095 | Pituitary and Neuroendocrinology 3 | ECE2019

Poor response to pre-surgical treatment with Somatostatin Receptor Ligands is associated with diabetes in patients with acromegaly

Tecilazich Francesco , Frara Stefano , Losa Marco , Formenti Anna Maria , Resmini Eugenia , Doga Mauro , Mortini Pietro , Giustina Andrea

Purpose: To evaluate whether the degree of response to surgical pre-treatment with somatostatin receptor ligands (SRL) predicts alterations in blood glucose levels.Patients and methods: We retrospectively studied 181 patients attending the Unit of Neurosurgery of our Hospital prior to transsphenoidal surgery. All patients had a diagnosis of acromegaly (nadir GH during OGTT >0.4 ng/ml; and IGF-I above age-standardized UNL); diagnosis of diabetes (DM) ...

ea0070aep592 | Pituitary and Neuroendocrinology | ECE2020

Morphometric vertebral fractures are highly prevalent in patients with non-functioning pituitary adenoma and related to older age and hypopituitarism

Frara Stefano , Di Filippo Luigi , Doga Mauro , Maria Formenti Anna , Losa Marco , Resmini Eugenia , Tecilazich Francesco , Mortini Pietro , Giustina Andrea

Introduction: Recent studies showed that morphometric vertebral fractures (VF) are an early and frequent complication in patients (pts) withhyperfunctioning pituitary adenomas and hypopituitarism (independently from the etiology). GH excess or severe deficiency play a negative key role on bone health in this clinical setting. Disease control or adequate replacement therapies still remain a cornerstone for the clinician to reduce the burden of osteo-metabolic complications. To ...

ea0049oc10.3 | Bone & Calcium Homeostasis | ECE2017

High prevalence of radiological vertebral fractures in patients with differentiated thyroid carcinoma undergoing L-thyroxine TSH-suppressive therapy

Formenti Anna Maria , Mazziotti Gherardo , Frara Stefano , Maffezzoni Filippo , Doga Mauro , Bertagna Francesco , Maroldi Roberto , Memo Maurizio , Giubbini Raffaele , Giustina Andrea

Thyroid hormones play a central role in the regulation of bone turnover and thyrotoxicosis is an established cause of secondary osteoporosis. Increased prevalence of reduced bone mineral density (BMD) has been reported even in patients with subclinical thyrotoxicosis such as those with differentiated thyroid carcinoma undergoing long-term L-thyroxine (L-T4) TSH-suppressive therapy. Morphometric vertebral fractures (VFs) are an early and clinically...

ea0070oc6.7 | Hot Topics (including COVID-19 | ECE2020

Hypocalcemia is highly prevalent and predicts hospitalization in patients with COVID-19

Di Filippo Luigi , Formenti Anna Maria , Rovere-Querini Patrizia , Michele Carlucci , Conte Caterina , Ciceri Fabio , Zangrillo Alberto , Doga Mauro , Giustina Andrea

Coronavirus disease 2019 (COVID-19), may lead to a severe acute respiratory syndrome requiring hospitalization and assisted ventilation with high lethality. Replication of SARS-CoV, MERS-CoV and Ebolavirus is calcium-dependent and hypocalcemia has been frequently reported in all these infections. Despite already many studies reporting on clinical and laboratory presentation of COVID-19 patients, including inflammatory and organ injury biomarkers, only one case report has so fa...