Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp81 | Thyroid Autoimmune Disorders | ECE2019

Retrospective analysis of the efficacy of three different dose regimens of rituximab in patients with active moderate-severe graves’ orbitopathy

Lazzaroni Elisa , Covelli Danila , Campi Irene , Vannucchi Guia , Curro Nicola , Pirola Giacinta , Guastella Claudio , Dolci Alessia , Arosio Maura , Salvi Mario

Aim: The aim of this retrospective study was to assess the efficacy of different doses of rituximab (RTX) in patients with active moderate-severe Graves’ Orbitopathy (GO).Methods: Overall 40 patients, 5 M/35 F; mean age (± S.D.) 58±11 years were treated with RTX; 21 were smokers. The patients received the following treatment: 14 patients (group 1) a single 100 mg dose; 15 patients (group 2) a single 500 mg dose and 11 Patien...

ea0070yi9 | Young Investigators | ECE2020

Comparison between the efficacy of the Anti-BAFF monoclonal antibody belimumab vs methylprednisolone in active moderate-severe graves’ orbitopathy: an interim analysis

lazzaroni Elisa , Covelli Danila , Currò Nicola , Campi Irene , Vannucchi Guia , Dazzi Davide , Muller Ilaria , Guastella Claudio , Dolci Alessia , Arosio Maura , Salvi Mario

Background: BAFF is a Serum B cell stimulating factor shown elevated in Graves’ disease, compared to controls (Vannucchi 2012). BAFF and its receptor are expressed on lymphocytes infiltrating the thyroid in Graves’ disease as well as on thyrocytes themselves (Campi 2015).Aims: A single-blind randomized controlled trial (EudraCT 2015-002127-26) has been conducted to test the efficacy of the anti-BAFF monoclonal antibody belimumab (BMB) in acti...

ea0070aep924 | Thyroid | ECE2020

Octreotide and pasireotide effects on medullary thyroid carcinoma (MTC) cells growth, migration and invasion

Catalano Rosa , Mangili Federica , Giardino Elena , Maria Barbieri Anna , Treppiedi Donatella , Dolci Alessia , Contarino Andrea , Spada Anna , Arosio Maura , Mantovani Giovanna , Peverelli Erika

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor of the parafollicular thyroid C cells. Although somatostatin (SS) receptors (SSTs) are expressed by MTCs, treatment with octreotide, specific for SST2, has shown poor efficacy in reducing MTC proliferation, whereas pasireotide, a multi-receptor SS analogue with preferential binding to SST5, has recently demonstrated antiproliferative effects in persistent postoperative MTCs. In vitro data in human MTC ce...

ea0070aep954 | Thyroid | ECE2020

TNM 8th edition in thyroid cancer staging: Is there an improvement in predicting recurrence?

Cellini Miriam , Alice Manzardo Olimpia , Indirli Rita , Dolci Alessia , Colombo Paolo , Carrone Flaminia , Lavezzi Elisabetta , Mantovani Giovanna , Mazziotti Gherardo , Arosio Maura , Lania Andrea

TNM 8th edition introduces changes in the staging of patients with differentiated thyroid carcinoma (DTC). This study aims at assessing the ability of TNM 8th edition in predicting structural recurrence of DTC.480 DTC patients were retrospectively evaluated by 7th and 8th editions of TNM staging systems in relationship with risk stratification, response to therapy and recurrence of disease as defined by 2015 American Thyroid Association (ATA) guidelines. As compared to the 7th...

ea0016p456 | Neuroendocrinology | ECE2008

Use of videocapsule endoscopy (VCE) for the detection of small bowel tumors in patients with acromegaly

Coletti Francesca , Lucia Ronchi Cristina , Montefusco Laura , Fesce Edoardo , Ogliari Cristina , Ferrante Emanuele , Epaminonda Paolo , Dolci Alessia , Adda Guido , Beck-Peccoz Paolo , Arosio Maura

A high risk for small bowel (SB) tumors in acromegalic population has been reported in a cohort study (Baris D, 2002). SB lesions may be easily investigated by the recently developed videocapsule endoscopy (VCE). Aim of the study was to assess the prevalence of SB neoplasms by VCE in 14 acromegalic patients (Ac) in respect to 30 sex and age-matched control subjects and to correlate it with cancer risk factors and acromegaly-related parameters. Local Ethical committee approved ...

ea0084op-11-54 | Oral Session 11: Young Investigators / Basic | ETA2022

Study of target tissue-resident immune cells in graves’ disease and orbitopathy (star-GO): preliminary findings with a novel extensive immunophenotyping panel

Maioli Sara , Salvi Mario , Moschetti Giorgia , Crosti Mariacristina , Crivicich Erica , Di Marco Francesco , Curro Nicola , Dolci Alessia , Arosio Maura , Mantovani Giovanna , Dayan Colin , Geginat Jens , Muller Ilaria

Background and Aims: Graves’ disease (GD) and orbitopathy (GO) are characterised by the presence of pathological anti-thyrotropin receptor antibodies. In thyroid autoimmunity, especially GD and GO, a dysregulation of several T cell subpopulations has been proposed, especially T regulatory (Treg) and T helper 17 (Th17) cells, determining (auto)immunity inhibition and enhancement, respectively. T follicular cells (Tf) within germinal centres (GC: aggregates of lymphocytes w...

ea0070aep1005 | Hot topics (including COVID-19) | ECE2020

Adrenal insufficiency at the time of COVID-19: A retrospective study

Carosi Giulia , Morelli Valentina , Del Sindaco Giulia , Cremaschi Arianna , Frigerio Sofia , Rodari Giulia , Indirli Rita , Liliana Serban Andreea , Profka Eriselda , Mungari Roberta , Resi Veronica , Orsi Emanuela , Ferrante Emanuele , Dolci Alessia , Giavoli Claudia , Arosio Maura , Mantovani Giovanna

Background: COVID-19 represents a global health emergency and infected patients with chronic diseases often present a severe impairment. Adrenal insufficiency (AI) is supposed to be associated with an increased risk of infections which could trigger adrenal crisis. Our primary aim was to evaluate the incidence of COVID-19 symptoms and complications in AI patients.Materials and methods: We conducted a retrospective case-control study, in 279 patients with...

ea0032p4 | Adrenal cortex | ECE2013

Long-term follow-up in adrenal incidentalomas: an Italian Multicentre Study

Morelli Valentina , Reimondo Giuseppe , Giordano Roberta , Casa Silvia Della , Muscogiuri Giovanna , Policola Caterina , Salcuni Antonio Stefano , Dolci Alessia , Beltrami Giulia , Palmieri Serena , Scillitani Alfredo , Arosio Maura , Ambrosi Bruno , Ghigo Ezio , Beck-Peccoz Paolo , Chiodini Iacopo , Terzolo Massimo

Introduction: The need of a long-term follow-up in adrenal incidentalomas (AI) is debated and data on cardiovascular events (CVE) are lacking.Methods: In this retrospective study all patients referred to seven Italian Endocrine Centers for AI, without signs of hypercortisolism at baseline and with a ≥5 years follow-up (80.7±30 months, range 60–286), were enrolled. From 171 patients (121 F) aged 59.5±10.2 years (range 25–79) the ...