Searchable abstracts of presentations at key conferences in endocrinology

ea0021p13 | Bone | SFEBES2009

Is it time to replace the 24 h urine calcium: creatinine clearance ratio in the investigation of PTH-dependent hypercalcaemia?

Cegla Jaimini , Saroya Sharan , McGowan Barbara , Donaldson Mandy , Tan Tricia

Background: Primary hyperparathyroidism (PHPT) and familial hypercalcaemic hypocalciuria (FHH) can both present with hypercalcaemia, but their management and prognosis are quite distinct. The 24 h urine calcium: creatinine clearance ratio (CCCR) is used to distinguish FHH from PHPT, where patients with FHH have a CCCR of <0.01. This study compares the use of a spot urine sample to measure CCCR with the gold-standard 24-h urine CCCR.Objective: To eval...

ea0015oc15 | Reproduction | SFEBES2008

Evaluation of the prevalence of vitamin D deficiency and its treatment in a West London pregnant population

Salmasi Huda , Banerjee Anita , Donaldson Mandy , Wren Alison M

Vitamin D deficiency is a particular concern in pregnancy as it can affect both mother and infant, with problems lasting into childhood. A high prevalence of deficiency during pregnancy has been reported among known risk groups. Current guidelines on supplementing pregnant women are conflicting, with universal replacement recommended by the Department of Health but not supported by NICE guidelines. We aimed to determine the prevalence of vitamin D deficiency in a West London p...

ea0028p32 | Clinical biochemistry | SFEBES2012

Vitamin D deficiency is associated with worsened biochemical features and poorer diagnostic accuracy in patients with primary hyperparathyroidism

Modi Manish , Jayasena Channa , Palazzo Fausto , Donaldson Mandy , Meeran Karim , Dhillo Waljit

Background: Vitamin D deficiency is a common feature of primary hyperparathyroidism (PHP). However, replacement of vitamin D is not routinely performed in clinical practice, due to concerns about its safety. Furthermore, it is not clear whether vitamin D deficiency worsens the biochemical derangements observed in patients with PHP.Aim: To determine the relationship between 25(OH) vitamin D status and biochemical markers in patients with PHP.<p class=...

ea0025p253 | Pituitary | SFEBES2011

Associations of overall GH and IGF1 exposure with ischaemic heart disease and cardiomyopathy in patients with treated acromegaly

Clarke Holly , Jayasena Channa , Comninos Alexander , Donaldson Mandy , Meeran Karim , Dhillo Waljit

Background: Patients with acromegaly require lifetime monitoring due to the excess mortality and morbidity associated with untreated disease, and the propensity for disease relapse following treatment. There is controversy whether GH or insulin-like growth factor 1 (IGF1), better predicts the onset of cardiovascular complications such as cardiomyopathy and ischaemic heart disease (IHD) in acromegalic patients.Aim: To examine associations of overall GH an...

ea0025p254 | Pituitary | SFEBES2011

Overall GH exposure is raised in acromegalic patients with type 2 diabetes and impaired glucose tolerance, when compared with euglycaemic acromegalic patients

Clarke Holly , Jayasena Channa , Comninos Alexander , Donaldson Mandy , Meeran Karim , Dhillo Waljit

Background: A cardinal feature of acromegaly is insulin resistance. Patients with acromegaly are therefore predisposed to developing impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM). It is therefore imperative to develop better biomarkers predicting the onset of IGT and T2DM in treated acromegalic patients. There is controversy whether GH or insulin-like growth factor 1 (IGF1) better predict the onset of IGT or T2DM in treated acromegalic patients. However ...

ea0018p31 | (1) | MES2008

Diagnostic cut-off for calcitonin: is 10 ng/l still valid?

Ramachandran Radha , Benfield Patricia , White Sara , Chapman Richard , Meeran Karim , Donaldson Mandy , Martin Niamh

Aim: Population studies have shown that basal calcitonin concentrations are below 10 ng/l in the normal population. Ten nanograms per liter is used as a diagnostic cut-off by most laboratories and patients with levels higher than this are offered a pentagastrin stimulation test to exclude medullary thyroid carcinoma. However, these guidelines were adopted from studies that used the Cisbio Immunoradiometric assay for measuring calcitonin. Most laboratories have now moved to che...

ea0025p318 | Thyroid | SFEBES2011

Serum phosphate predicts temporary hypocalcaemia following thyroidectomy

Sam Amir H , Dhillo Waljit S , Donaldson Mandy , Moolla Ahmad , Meeran Karim , Tolley Neil S , Palazzo Fausto

Background: Temporary hypocalcaemia occurs in up to 40% of patients following a total thyroidectomy. Serum calcium and parathyroid hormone (PTH) measurements are currently used to predict post-thyroidectomy hypocalcaemia. However, immediate access to PTH measurement is expensive and not widely available. Serum phosphate responds rapidly to changes in circulating PTH levels and its measurement is readily available in all hospitals. We evaluated the use of serum phosphate to pre...

ea0021p118 | Clinical practice/governance and case reports | SFEBES2009

Salivary cortisol is a reliable marker to monitor hydrocortisone replacement

Pahilwani Bharat , Darch Sarah , Ramachandran Radha , Cegla Jaimini , Nijher Monica , Meeran Karim , Chapman Richard , Donaldson Mandy , Tan Tricia

Context: Hydrocortisone day curves (HCDC) are used to monitor hydrocortisone replacement by obtaining serum samples to measure cortisol levels throughout the day. Salivary measurement of free cortisol offers a non-invasive alternative to serum measurements.Objective: To validate salivary cortisol measurement as an alternative method to assess the adequacy of hydrocortisone replacement in patients with hypoadrenalism.Setting, patien...

ea0025p269 | Reproduction | SFEBES2011

Kisspeptin-54 injection stimulates activity of the human GnRH pulse generator in healthy women

Jayasena Channa N , Comninos Alexander N , Misra Shivani , Ali Abbara , Aniket Tavare , Donaldson Mandy , Ghatei Mohammad A , Bloom Stephen R , Dhillo Waljit S

Background: Kisspeptin is a novel hypothalamic hormone with powerful stimulatory effects on the hypothalamo-pituitary–gonadal (HPG) axis. Inactivating mutations in the kisspeptin receptor lead to pubertal failure. We have previously demonstrated that injection of kisspeptin-54 stimulates LH release in healthy men and women. Recent studies in animals suggest that endogenous kisspeptin may be involved in stimulating the GnRH pulse generator. Determining whether exogenous ad...

ea0013oc17 | Novartis Clinical Endocrinology Award | SFEBES2007

Kisspeptin-54 potently stimulates luteinising hormone release during the preovulatory phase of the menstrual cycle in healthy human females.

Chaudhri Owais , Dhillo Waljit , Thompson Emily , Murphy Kevin , Salem Victoria , Patterson Michael , Donaldson Mandy , Amber Vian , Ramachandran Radha , Nijher Gurjinder , Kokkinos Alexander , Ghatei Mohammad , Bloom Steve

Kisspeptin, the endogenous ligand of the GPR54 receptor, is a key regulator of the hypothalamo-pituitary-gonadal (HPG) axis. GPR54-null mice exhibit reproductive dysfunction and exogenous kisspeptin potently stimulates the HPG axis in rodents, primates and human males. The effects of kisspeptin administration to human females are not known.Aim: To investigate the effects of kisspeptin on luteinising hormone (LH) release during the menstrual cycle in fema...