Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1219 | Clinical case reports - Thyroid/Others | ECE2017

Struma ovarii – A report of thirteen cases

Donato Sara , Simoes Helder , Leite Valeriano

Introduction: Struma ovarii (SO) is a rare ovarian teratoma characterized by the presence of thyroid tissue in >50% of the tumour. Malignant transformation is rare and defined by the same histological criteria as for thyroid cancer. There is few data on the literature and treatment is controversial. The objective of this study was to describe the clinical, pathologic and treatment characteristics of women diagnosed with SO in our centre.Methods: Retr...

ea0090p520 | Thyroid | ECE2023

Change in mucosal pigmentation following treatment with radioactive iodine

Verissimo David , Rombo Diogo , Ferreira Teresa , Donato Sara

Introduction: Treatment using radioactive iodine (RAI) is used in several thyroid diseases, including differentiated thyroid carcinoma (DTC). The most frequent adverse effects include acute gastrointestinal symptoms, sialadenitis, xerostomia, cervical pain, and cervical swelling. Chronic symptoms such as obstruction of the salivary ducts, pulmonary fibrosis or other primary malignant diseases are also described. A single case of change in tongue pigmentation / lingua villosa n...

ea0049ep772 | Clinical case reports - Thyroid/Others | ECE2017

Immune checkpoint inhibitors related thyroiditis – a report of two cases

Donato Sara , Antunes Pedro , Simoes-Pereira Joana , Simoes Helder

Introduction: Immune checkpoint inhibitors (ICPIs) are recent approved drugs used in malignant melanoma, non-small-cell lung cancer and renal cell cancer. They act by activating host T cell against malignant antigens. Immune checkpoint blockade can lead to breaking of immune self-tolerance, thereby inducing autoimmune/autoinflammatory side effects, such as endocrinopathies. It may affect thyroid, adrenal and pituitary. We present two ICPIs induced thyroiditis cases.<p clas...

ea0049ep783 | Endocrine Disruptors | ECE2017

Endocrine dysfunctions associated with Hodgkin Lymphoma treatment

Dias Daniela , Simoes-Pereira Joana , Donato Sara , Pereira Conceicao

Introduction: Hodgkin lymphoma (HL) survivors may develop a range of long-term complications that arise years after therapy. Among these, the endocrine dysfunctions are a major concern. Aim: To investigate the long-term endocrine effects of HL treatment.Methods: Revision of the HL patientsÂ’ medical files who were followed at our Endocrine Late-effects Clinics.Results: We studied 178 patients (86 (48.3%) were female), whose mea...

ea0049ep788 | Endocrine tumours and neoplasia | ECE2017

Endocrine health problems detected in 764 patients evaluated in a late effects clinic

Pereira Conceicao , Pereira Joana , Dias Daniela , Donato Sara , Salgado Dauarte

Context: Many pediatric cancer survivors have endocrine conditions. After alkylating agents, steroids, methotrexate and radiation, several endocrine dysfunctions may appear. Surveillance for late effects is recommended by worldwide guidelines.Objective: The objective of the study was to describe the endocrine outcomes of 764 patients followed during a 20 years period in our out-patient clinic.Design: The design was a retrospective ...

ea0049ep1142 | Female Reproduction | ECE2017

How far is possible to make a diagnosis of infertility

Dias Daniela , Simoes-Pereira Joana , Donato Sara , Pereira Conceicao

Introduction: Chemotherapy may be an important cause of primary infertility, especially in girls submitted to this therapy at very young ages.Clinical case: A 20-year-old female was diagnosed with acute lymphoblastic leukaemia at the age of 1. She was submitted to chemotherapy: intrathecal methotrexate and cyclophosphamide and i.v. doxorubicin, vincristine, mercaptopurine, asparaginase and bone marrow transplantation at the age of 2. She was ref...

ea0070ep576 | Hot topics (including COVID-19) | ECE2020

Challenges in hyponatremia etiology and management in a child with a suprasellar tumour

Donato Sara , Figueiredo Ana , Simões-Pereira Joana

Introduction: Hyponatremia is the most common hydroelectrolytic disturbance in clinical practice. Multiple causes exist for its occurrence, being the etiological diagnosis sometimes complex. In patients with suprasellar tumours it is even harder due to several confounding factors. Management of these patients is difficult as it conflicts with chemotherapy-associated hyperhydration protocols. We present a case that exemplifies this.Clinical case: Four yea...

ea0056ep23 | Adrenal and Neuroendocrine Tumours | ECE2018

Intestinal pseudo-obstruction as a fatal complication of a malignant hereditary paraganglioma: A case report

Maciel Joana , Donato Sara , Simoes Helder , Leite Valeriano

Background: Familial paraganglioma type 1 syndrome is a hereditary form of paraganglioma due to an autosomal dominant, paternally inherited, germinal mutation in the SDHD subunit. Intestinal pseudo-obstruction is a rare complication of secretory PGL. We present a case of a patient with a malignant PGL syndrome type 1 who developed intestinal pseudo-obstruction.Clinical case: The patient was a Dutch male, aged 39 years, carrier of a germinal mutation in e...

ea0081p282 | Adrenal and Cardiovascular Endocrinology | ECE2022

Behavior of metastatic paragangliomas and pheocromocytomas: experience from a single center

Verissimo David , damasio ines , Gomes Ana , Simoes-Pereira Joana , Donato Sara , Leite Valeriano

Paragangliomas (PGL) and pheochromocytomas (PHEO) are rare neuroendocrine tumors with an estimated prevalence of 1:6500 and 1:2500, respectively. Although most PGL/PHEO are benign, approximately 10% of PHEOs and 15-35% of PGLs have metastatic disease, which it is main cause of death, with 6 years of median survival. Objective: To characterize the metastatic PHEOs and PGLs from a single center. Methods: Retrospective analysis of clinical records of patients with metastatic PHEO...

ea0067gp15 | Poster Presentations | EYES2019

Challenges in the management of severe constipation due to metastatic paraganglioma

Figueiredo Ana Abrantes , Maciel Joana , Cavaco Daniela , Donato Sara , Simoes Helder , Simoes-Pereira Joana , Leite Valeriano

Background: Pheochromocytoma and paragangliomas (PPGLs) are rare disorders with a rate of malignancy of 10–20%. The control of the hormonal symptoms caused by the catecholaminergic burden in the metastatic disease is a challenging task. Hypertension is the most recognized feature, but gastrointestinal manifestations can be hard to manage and life-threatening.Cases Presentation: We present three cases of metastatic PPGLs who developed intestinal pseu...